James Purcell
Research Fellow - Oncology Discovery at AbbVie
- Role
- Research Fellow at AbbVie
- Location
- South San Francisco, CA, US
- LinkedIn followers
- 500 followers
About James Purcell
Cancer biologist with extensive experience in oncology drug discovery, in vivo translational studies, target validation and drug mechanism of action studies.My focus at Abbvie involves identifying and validating the mechanism of action and activity of novel biologics for use as future cancer therapies. I am currently the research lead for a clinical stage antibody drug conjugate program.Previous work involved establishing and managing the running of Cytokinetics in-house in vivo oncology efforts. This work focused on tumor efficacy, mouse tolerability, pharmacokinetic and pharmacodynamic studies on their small molecule anti-mitotic oncology compounds. I also was involved in early oncology discovery efforts including in vitro target validation.Previous experience include mechanisms of chemoresistance to DNA-damaging agents and transcription factors associated with drug sensitivity in breast cancer.Specialties: Cancer biology, pharmacology, drug development, study/project management, in vivo models, cell signaling and cell biology techniques
Experience
Research Fellow
Jul 2021 — Present
Education
Trinity College Dublin
BSc, Biochemistry
1997 — 2001
Queen's University Belfast
PhD, Resistance to DNA damage therapy in BRCA1 breast cancer
2002 — 2006
The Royal College of Physicians in Ireland
MSc, Molecular Medicine
2001 — 2002
Skills
- Immunology
- Assay Development
- Lifesciences
- Oncology
- Antibodies
- Cell Signaling
- Elisa
- Life Sciences
- Pharmacology
- Cell Culture
- In Vivo
- Translational Medicine
- Drug Discovery
- Cell Biology
- In Vitro
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