Jaideep Saha
Assistant Professor Medicinal Chemistry @National Institute Of Pharmaceutical Education And Research
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WORK HISTORY
Assistant Professor Medicinal Chemistry @National Institute Of Pharmaceutical Education And Research
Mohali district, IN
Research Areas: Synthetic chemistry driven medicinal chemistry, development of chemical probes and preclinical drug-discoveryResearch group URL: https://jaideepsaha-cbmr.weebly.com/New synthetic methods: Strain-release driven transformations catalytic methodologies (transition metal) to elusive and medicinally relevant heterocycles metal-based cross coupling reactions development of metal-free tandem/ cascade reactions MHAT-based catalytic transformation radical-reactions photo-redox catalysis carbene chemistry spiro-cycles late-stage functionalization of drugs and bioactive compounds Medicinal chemistry: Lead generation ― pre-clinical development: Antimicrobial; anticancer; antidiabetic agents SAR studies scaffold-hopping development/ use of bioisosteres molecular docking late-stage functionalization drug-metabolism targeted delivery of bioactive agentsCarbohydrate chemistry: Multi-step synthesis-purification-analysis-structural characterization of complex carbohydrates oligosaccharides carbohydrate mimetics sialic acids lectin-carbohydrate interactions Inhibitor design Peptide chemistry: Liquid and solid phase synthesis cyclic peptides peptidomimetics site-selective modification
EDUCATION
Calcutta University
B.Sc, Chemistry
The University of Connecticut
PhD, Synthetic Organic Chemistry
Indian Institute of Technology, Madras
M.Sc, Organic Chemistry
ABOUT JAIDEEP SAHA
research group webpage URL: http://jaideepsaha-cbmr.weebly.com/ We leverage our interest and expertise in making small functional molecules to connect projects in the area of chemical biology and medicinal chemistry, that run in collaboration with different biology groups of complementary interest. Since the screening of small molecules against various targets have become a prominent exercise in various drug-discovery programs, our interest on design and synthesis of elusive and unconventional molecular scaffolds in library fashion has provides an alternative means in this regard to replace commonly used store-bought compound libraries. In fact, many of our compounds have the natural-product like features, making them more attractive scaffolds for evaluating the biological properties.
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