Jacquelyn Jhingree
Principal Scientist @Bioinformatics Solutions Inc
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WORK HISTORY
Principal Scientist @Bioinformatics Solutions Inc
Waterloo, ON, CA
Mass spectrometry subject matter expert (SME)• Collaborating with various teams to leverage and improve computational tools for comprehensive monoclonal and polyclonal antibody characterization with high resolution mass spectrometry approaches.• Lead and collaborate in the development of high resolution mass spectrometry approaches (LC-MS, LC-MS/MS with CID and ETD fragmentation) for antibody proteoform characterization with a focus on a combined strategy utilizing bottom-up, top/middle-down and intact mass analysis.
EDUCATION
The University of Manchester
Doctor of Philosophy - PhD, Chemistry (Ion Mobility Mass Spectrometry, Protein Characterization)
University of Guyana
Bachelor of Science - BSc, Chemistry
ABOUT JACQUELYN JHINGREE
Technical Scientific Leader, Mass Spectrometry Subject Matter Expert (SME), and Hands-on Experimentalist with 15+ years of experience designing, developing and implementing analytical methodologies for biomolecule characterization. Authority in the structural characterization of biologics, oligonucleotides and small molecules including siRNA, ASOs, mRNA, DNA, mRNA-LNPs, antibodies, and their conjugates. Expert in designing robust LC-MS and LC-MS/MS workflows—including Ion-Pairing-RP, HILIC, HIC, IEX, and SEC—leveraging high resolution mass spectrometry and other analytical technologies to solve complex analytical challenges and ensure product integrity, comparability and process stability across various development stages in the pharmaceutical industry.Technical Skills/Instrumentation:Mass Spectrometry: High-Resolution Orbitrap (Fusion Lumos Tribrid, Exploris 240 and 120, Q-Exactive, LTQ-XL), Waters Q-ToF (Ultima, Synapt G2, G2-Si), Bruker (timsTOF Pro II, FT-ICR, MALDI-ToF), Agilent 6550 iFunnel, and Triple Quadrupole systems.Ion Mobility: Homebuilt Linear Drift Tube IM-MS (based on Q-ToF instruments), Waters Travelling Wave IM-MS (TWIMS), Bruker Trapped IM-MS and Owlstone FAIMS/DMS.Chromatography: UPLC/UHPLC and Nano-flow systems (Waters, Thermo, Agilent, Eksigent)- including RP, IP-RP, SEC, IEX, HILIC, HIC, and CAD detection; general GC.Biophysics & Spectroscopy: SEC-UV-MALS-RI (Waters-Wyatt Triple Detection), SPR (Biacore Circular Dichroism (CD),(CE) UV-Vis, Fluorescence, and Atomic Absorption Spectroscopy (AAS).Systems Engineering: Hands-on expertise in prototype testing, vacuum system maintenance, gas-line plumbing, and hardware troubleshooting/disassembly/assembly.Software: MassLynx, BioPharma Finder, Byonic, Mascot, Empower, Chromeleon, Xcalibur, ChemStation, OpenLab CDS, BioConfirm, MassHunter, Bruker Data Analysis, PEAKS, Proteoform X and PolySeQ.AI.
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