Jacob Jake Martin
PhD bioengineer with versatile skills and experience
- Role
- Associate Director of Analytical Development, Biochemistry & Microbiology at Halozyme, Inc.
- Location
- Cambridge, MA, US
- LinkedIn followers
- 500 followers
About Jacob Jake Martin
Scientific team leader with 17 years bioengineering R&D experience: • Supervision / training of at least 12 scientists / technicians throughout various positions in academia and industry• Downstream Process & Analytical Development: extracellular vesicle (EV), AAV, adenovirus (Ad5), and recombinant protein production, purification, characterization, conjugation, and engineering• Strong project and people management, organization, and communication skills
Experience
Associate Director of Analytical Development, Biochemistry & Microbiology
Sep 2024 — Present · Boston, MA, US
Leading the Biochemistry & Microbiology subteam in Analytical Development for a platform technology called Hypercon that enables reformulation of protein therapeutics (monoclonals, bispecifics, fragments, conjugates, etc.) into ultra-high concentration (500+ mg/mL) microparticle suspensions. Began this role with Elektrofi and continued with Halozyme after the acquisition in Nov 2025.Managing a team of eight members (two Sr. Scientists, one Scientist, two Sr. Assoc. Scientists, and three contractors) specializing in various protein quality assays and microbio assays. The chromatography techniques run by the team make use of HPLC / UHPLC / UPLC instruments with UV, CAD, or MS detectors. SEC, RP, or multimodal columns are used to characterize HMW protein aggregates and various excipients or surfactants such as polysorbate. Capillary electrophoresis methods such as CE-SDS and iCIEF are also used for analyzing protein degradation and charge variants. A USP compliant Apparatus 4 flow-through cell instrument is used to measure DP dissolution / in vitro release time of the API, sometimes including the use of subcutaneous injection site models. Bacterial endotoxin (BET) and sterility / bioburden testing are also performed by my team or outsourced to contract testing labs if GMP testing is required.Representing the AD team on a project to produce clinical trial material (CTM) for Phase 1 in collaboration with a large cap pharmaceutical industry partner and a CMO. Also contributing to evaluations of potential new feasibility/pilot programs with new or existing partner companies.Reviewing and approving technical documents such as ELN entries, SOPs, tech reports, and method qualification reports.
Education
University of Connecticut
Bachelor's Degree, Chemical Engineering
2004 — 2008
Rensselaer Polytechnic Institute
Doctor of Philosophy (Ph.D.), Chemical Engineering
2008 — 2014
Skills
- Chemical Engineering
- Chromatography
- Confocal Microscopy
- Nmr
- English Grammar
- Protein Purification
- Google Docs
- 1h Nmr
- Biochemistry
- Protein Expression
- Hplc
- Characterization
- Affinity Chromatography
- Sec
- Spectroscopy
- Microsoft Office
- Organic Chemistry
- Elisa
- Ion Exchange
- Aptamers
- Fluorescence Spectroscopy
- Dls
- Bioconjugation
- Protein Chemistry
- Gel Electrophoresis
- Microsoft Excel
- Powerpoint
- Size Exclusion
- Akta
Find verified contacts for anyone on LinkedIn
Unifers gives sales teams verified emails and direct dials, enriched profiles, and outreach that lands in the inbox.
Free plan included · No credit card required
This profile is compiled from publicly available professional sources. Unifers is not affiliated with or endorsed by LinkedIn. Request removal of this profile.