Hugh McCabe
Student-Athlete at Bates College Studying Biochemistry & Economics
- Role
- Research Intern at Mit Department Of Chemistry
- Location
- Arlington, MA, US
- LinkedIn followers
- 500 followers
Experience
Research Intern
Jun 2025 — Present · Cambridge, MA, US
Project centered on the multistep synthesis of unique amino acid substructures, with a particular emphasis on components found in natural product antibiotics such as himastatin.Key Responsibilities:Synthesize complex unnatural amino acids, including piperazic and hydroxypiperazic acid derivativesConduct asymmetric alkylation reactions to evaluate enantioselectivity and optimize reaction conditionsAnalyze products using advanced analytical techniques such as NMR, HPLC, and LCMSExecute precise synthetic procedures including monitoring, workups, isolation, and purificationScale reactions to access multigram quantities of enantioenriched amino acidsPerform enantioselective synthesis of both enantiomers of piperazic acid derivativesExtend synthetic methods to more complex, substituted unnatural amino acids relevant to total synthesis targetsCollaborate closely with research mentors to troubleshoot synthetic challenges and refine experimental strategies
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