Hongyu Xue

About Hongyu Xue

In Vivo Pharmacology| Disease Modeling| Oncology| Immunology| Multidisciplinary knowledge and skill sets| Managing CRO Studies| Experiment Design & Execution| Endpoint Determination| Mechanism of Action Exploration| Critical Thinking & Strategic Planning| Project Management• Unique ability to leverage comprehensive knowledge in animal and human pathophysiology to generate hypotheses, devise and execute experiments for hypotheses testing and work through complex mechanism of action aspects to formulate targeted solutions• Experience in various in vivo disease modeling and possess acumen and adaptability to perform multidisciplinary research cross-linking oncology, immunology, inflammation, microbiology, gastroenterology, and critical care• Experience in the preclinical small molecule drug development through discovery spanning MOA exploration, disease modeling, lead optimization, and selection of clinical candidate • Establishing and managing interactions with CROs, academic institutions, and other external partners• Hands-on experience in various oncology modeling (CDX, syngeneic, and GEMM) and a wide variety of in vivo techniques • Sharp critical thinking skills and ability to develop a well-balanced and strongly defended scientific position• Proactively employ the entrepreneurial spirits in directing R&D efforts and project management• Scientific acumen in optimizing and customizing nonclinical/preclinical models and identifying clinically relevant and meaningful endpoints• Dynamic, creative, self-motivated and passionate to solve problems• Proven record of supervising research teams• Experience in driving cross-functional initiatives and promoting synergistic and collaborative partnership across various functional players

Experience

1. Director in Vivo Pharmacology, Oncology Research

   Bayer

   Jan 2022 — Present · Cambridge, MA, US

   Act as In Vivo Pharmacology point person for research portfolio specific in vivo goals;• Establish in vivo strategy and oversee execution of in vivo pharmacology studies including developing/selecting tumor model, exploring mechanism of action of lead compounds, analyzing and interpreting PK/PD relationships, and testing biomarker hypotheses in vivo• Expand and grow internal in vivo pharmacology capabilities. Develop strategy to efficiently use internal and external resources to generate high quality data for the decision making of various drug discovery programs• Establish and empower standardization of study design, QC, and results analysis• Establish and manage collaborations with external CROs to deliver high quality in vivo pharmacology data packages• Examine novel disease models for potential oncology drug discovery application in efforts to comply with the 3R principle of animal research• Key responsible person for animal study protocol development, including regulatory submissions and licensure activities• Key Interaction partner for on-site animal care management team• Serve on cross-functional project teams as the in vivo expert• Collect and analyze data from various assays, track and trend data, and establish specifications for critical process controls

Education

• University of Alberta

  Doctor of Philosophy (PhD), Oncology Nutrition

• Peking Union Medical College

  Doctor of Medicine (M.D.), Medicine

Skills

• Nutrient-Drug Interaction
• Cancer Research
• Public Health
• Prebiotics and Probiotics
• Gene Regulation
• Nutrition Research
• Life Sciences
• Research
• Amino Acid Nutrition
• Micronutrients
• Clinical Nutrition
• Fish Oil Nutrition
• Preclinical Trials
• Nutrition
• Medicine
• Cancer Supportive Care
• Macronutrient
• Immunology
• Cancer
• Cancer Chemotherapy
• Biotechnology
• Clinical Trials
• Pharmaco-Nutrients
• Toxicology
• Intestinal Physiology
• Cachexia
• Healthcare
• Molecular Biology
• Biochemistry
• Oncology