Hayretin Yumerefendi
Associate Director & Group Leader @Novartis
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WORK HISTORY
Associate Director & Group Leader @Novartis
Cambridge, MA, US
Lead a high-performing group of 14 scientists (across 4 teams) specializing in both (phage & yeast) and (hybridoma & B-cell) antibody discovery, with a focus on delivering innovative therapeutic candidates.• Oversee the end-to-end management of multiple therapeutic projects across diverse therapeutic areas, including immunology, oncology, cardiovascular, metabolic diseases, and kidney disorders.• Spearhead internal and external innovation initiatives, identifying and cultivating novel technologies and partnerships to drive drug discovery progress.• Manage key operational functions, including budgeting, resource allocation, and strategic planning, to ensure efficient execution and alignment with organizational goals.• Collaborate across matrix teams to integrate expertise from various disciplines and drive cross-functional success in advancing biologic therapeutics.
EDUCATION
European Molecular Biology Laboratory (EMBL-Grenoble)
PhD, Structural Biology
Jacobs University Bremen
BSc, Biochemical Engineering
ABOUT HAYRETIN YUMEREFENDI
I’m passionate about harnessing the molecular basis of life to engineer proteins and develop innovative biologics that tackle some of healthcare\'s most complex challenges. With a career spanning diverse roles and geographies, I thrive at the intersection of science, technology, and leadership:• Associate Director overseeing a high-performing group of 14 in biologics discovery and automation.• Proven expertise in project inception, strategy, and execution for therapeutic innovation.• Mentored and supervised 40+ scientists across diverse skill levels and cultural backgrounds, fostering growth and collaboration.• Extensive experience leading cross-functional and multicultural teams in the USA, Germany, and France. & :• Comprehensive experience in antibody discovery and engineering.• Specialization in Fc engineering for tailored properties (e.g, serum half-life, effector function modulation, bispecifics).• Expertise in antibody speciation, affinity maturation, and multispecific antibody design.• Skilled in identifying and mitigating antibody liabilities to enhance therapeutic efficacy (immunogenicity & developability)- Advanced proficiency in protein modeling and design using Rosetta and related computational tools- Extensive experience in high-performance computing (HPC) environments and Unix-based systems- Skilled in scripting and analysis with Python, BASH, and familiar with C++ and R- Experienced in next-generation sequencing (NGS) data analysis for biologics discovery:• Developed and optimized directed evolution screens and selections, including protein display platforms.• Expert in molecular biology, protein expression, purification, and biophysical characterization.• Proficient in analyzing protein structure, stability, and interactions using advanced biophysical methods.• Hands-on experience with mammalian cell culture, microscopy, and cell line engineering using CRISPR and lentiviral systems:• Contributed to patents and publications that reflect innovation in biologics and therapeutic development.• Led computational design and wet-lab experiments that advanced therapeutic projects to the clinic.• Built scalable platforms for antibody discovery and engineering, streamlining R&D pipelines.I’m always eager to connect with like-minded professionals to explore opportunities for collaboration and innovation.
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