Haiyan
Director, Research at Alnylam Pharmaceuticals
- Role
- Director at Alnylam Pharmaceuticals
- Location
- Cambridge, MA, US
- LinkedIn followers
- 500 followers
About Haiyan
Highly motivated, passionate, research focused Neuroimmunologist with interdisciplinary skills. Extensive training in neuroscience, immunology, cellular and molecular biology. Strong, positive communicator and enthusiastic collaborator internally and externally.Dedicated to applying skill-set in translation research to combat neurological disorders.Research Interests:neurological diseases diseases including AD, stroke, ALS and PD, innate immunity, autoimmune diseases and Macrophage/microglia associated neuroinflammation Sample Collection: Tissue Necropsy, Brain/spinal cord/peripheral organ micro-dissection, spinal cord flush/extraction, intravenous blood collection/cardiac punctureAnimal Models/Surgery: EAE, Middle Cerebral Artery Occlusion (MCAO for Ischemic Stroke), Spinal Cord Injury via stereotaxic microinjection, transcardial perfusion, use of isoflurane /oxygen apparatus for anesthesia administration, euthanasia Cellular/Molecular Skills:ELISA, Meso Scale Discovery (MSD), Luminex, Westerblot, qRT-PCR, FACS, MACS, Immunohistochemistry, luciferase activity assay,XF-96 Analyzer (Seahorse)Cell Culture: Mouse: Primary CNS cell culture (Neurons, microglia and astrocytes); Primary Immune Cell Culture (dendritic cells, T cells and macrophages), in vivo generation of Dendritic cells and ex vivo isolation of microglia via FACS Sorting, ex vivo isolation of macrophages via MACSHuman: PBMCs, CD3 T cell culture and monocytes derived macrophagesHistology/imaging: ArrayScan™ XTI High Content Analysis (HCA) Reader, Confocal Miscopy, Tissue sectioningData Analysis:Microsoft office, Flow Jo, GENE-E, Ingenuity, SpotFire, GraphPad, Expression Suite, EthoVision XT 8.5, Image J, XF wave, QuantStudio 12 Flex
Experience
Director
Feb 2025 — Present · Cambridge, MA, US
Education
Sichuan University
Master's degree
Sichuan University
Bachelor's degree
The Ohio State University
Ph.D
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