Gregory Jones

About Gregory Jones

Analytical Scientist with more than nine years of liquid chromatography experience in…

Experience

1. Principal Scientist, Analytical Development and Characterization

   Alnylam Pharmaceuticals

   Jan 2021 — Present

   Lead the technical deliverables and activities for achieving project milestones in matrix teams comprising of AD, QC, QA, regulatory CMC, and program teams. • Developed, qualified, transferred, and validated multiple LC-MS and GC-MS based CMC assays (impurity characterization, sequence confirmation, structure confirmation, genotoxic impurities) for novel siRNA therapeutics and their starting materials from early stage to post-commercial stages. • Lead matrix teams which performed method readiness assessment and transfer to multiple testing sites (internal QC and CMO/CTL) in parallel to support in process control, release testing, and purity/impurity methods for raw materials, intermediates, and excipients. • Conducted stability forced degradation characterization and genotoxic impurity assays supporting process development and QC release testing of cGMP manufacture from pre-clinical to commercial stages. • Advanced the state of the art in oligonucleotide impurity characterization (GC, LC, SFC) by directing capital expenditures and developing novel strategic separation technologies resulting in industry leading technical capabilities including: Multiple Custom LC-MS purification platforms at multiple scales to automate various impurity characterization workflows for oligonucleotides and their formulations (including conjugates and lipid nanoparticles) in support of non-GMP and GMP activities. Conceptualized, refined, and implemented a multi-dimensional impurity characterization platform that significantly increased the efficiency (>3x faster) and sensitivity (>3 logs) of the impurity characterization workflow. This strategic capability results in richer data sets, expanded impurity characterization capacity, and achieves this without increasing headcount.

Skills

• Science
• Analytical Chemistry
• Cell Culture
• Uv/Vis
• Life Sciences
• Fluorescence
• R&D
• Chromatography
• Gas Chromatography
• Mass Spectrometry
• Validation
• Lc-Ms
• Laboratory
• Cell
• Characterization
• Statistics
• Research
• Experimental Design
• Food Science
• Teaching
• Separation Science
• In Vitro
• Purification
• Analytical Instrumentation Installation/Repair
• Spectroscopy
• Elisa
• Data Analysis
• Gc-Ms
• Microsoft Office
• Biochemistry
• R
• Laboratory Safety
• High Performance Liquid Chromatography
• Drug Discovery
• Hplc-Ms
• 2d-Hplc
• Sas
• Preparative Hplc
• Chemistry
• Separations