Grace Chappell

Experience

1. Toxicologist

   ICF

   Aug 2022 — Present

   Dr. Grace Chappell is a toxicologist with experience investigating and assessing the underlying molecular mechanisms of various toxicological outcomes, with a specialty in carcinogenesis associated with exposure to chemicals commonly found in the environment and/or occupational settings. She received her M.S. in Public Health and Ph.D. in Environmental Sciences and Engineering from UNC-Chapel Hill by completing research on epigenetic mechanisms and transcriptomic changes involved in chemical-induced carcinogenesis. She has practical and analytical experience in a variety of molecular and cellular assays. Dr. Chappell is skilled in computational methods and tools for analyzing large “-omics” data sets and developing strategies for data visualization. She has contributed mechanistic expertise to several mode-of-action and weight-of-evidence assessments for a variety of compounds. She also has experience in reviewing, evaluating, and integrating high-throughput screening (HTS) assay data available through the ToxCast/Tox21 programs into various types of toxicity or hazard assessments. Dr. Chappell has contributed to several systematic reviews, the majority of which focused on the evaluation of mechanistic data as they relate to cancer.