George A. Karam
Protein Chemistry Target Development & Management @Biosynth
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WORK HISTORY
Protein Chemistry Target Development & Management @Biosynth
Gardner, MA, US
Protein Target Development & Management. Interfaces with Biosynth leads, partners, clients, and contractors to coordinate and manage protein and antibody development projects.
EDUCATION
Yale University School of Medicine
Dept of Biochemistry
Iowa State University
Doctor of Philosophy (Ph.D.)
SKILLS
ABOUT GEORGE A. KARAM
Protein biochemist with experience in protein discovery research, development, expression and generation for Structure, Screens, and antibody development. Antibody research, development, humanization, and recombinant generation. Strategic & operational external scientific partnerships & outsourcing. Global, cross-partner project management in Discovery and Preclinical stages. Identified new markets, CROs, CDMOs, technologies, & developed/led processes & international partnerships for multiple disease areas. Provided significant contributions to advancing small molecule & biotherapeutic drugs (Xeljanz, torcetrapib, tenazumab, rituximab, trastuzumab, Leptin, Insulin) & developed prophylactics & vaccines. Works with multiple global academic institutions, research centers, CROs, and CDMOs for development of protein drugs and drug targets. Developed, implemented & led global sourcing strategies, operational best practices & continuous improvement. Managed $MM budgets & international partnerships (US, EU, Asia). Aligned globally with Leaderships. Led cross-functional teams. Delivered a portfolio of NCE & biotherapeutic targets & assaysPartnered with the FDA & EMA to address regulatory requirements, develop clinical assays & drug standards, & to evaluate drug substance, solubility, QTPP & CMC/CQA validation & HCP/DNA analysis.Managed >150 internal & external FTEs with senior reports, to deliver a global portfolio supporting therapeutic space from idea to lead dev. & spanning preclinical, development, clinical safety, validation & manufacturing for small molecules & biotherapeuticsProvided global leadership. Collaborated with academics & Industry leads. Educated partners across industry. Published, presented, & organized symposia. Delivered keynotes in US, Europe, and AustraliaSpecialties: Strategic consulting. External research outsourcing & innovation leadership, protein/cell development, bioanalysis, validation for NCEs & NBEs. Multitasking project, budget & vendor management. Developing, enhancing & operationalizing complex portfolios, externally & internally. Leading multifunctional teams. Talent training & mentoring. Portfolio transitioning, development of strategies & operational guidelines, legal guidance & cost negotiations. Development of management tools. Communication, publishing & partnering skills
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