Giacomo Canesin

About Giacomo Canesin

Highly accomplished Principal Scientist experienced in leading R&D activities from early discovery through initiation of FIH clinical studies. Solid scientific background in cancer biology and Immuno-Oncology, with a strong track record of leading the successful development of drug candidates across different modalities, including gene therapy products, CAR-Ts and ADCs. Expertise spans from lead candidate screening & identification to in vitro characterization and potency evaluation, in vivo pharmacology, pharmacodynamics and toxicology assessments, assay development/validation/qualification for translational data generation and early clinical evaluation. Results-driven and collaborative, intellectually and scientifically curious, dedicated to innovative, high-quality research, while fostering a positive and creative work environment. • Translational Medicine: Development and implementation of biomarker strategies for efficacy prediction, assessment of biological activity and identification of responsive populations; proven experience in assay development, validation and qualification for translational data generation; implementation of ddPCR, single cell RNAseq, TCR/BCR repertoire and flow-based assays for immune cells detection in patients’ blood and bone marrow; development of translational study plans for Phase I/II and Phase trials; processing and analysis of patients’ samples, data generation, interpretation and communication.• In vivo Biology: Use of immunodeficient and immunocompetent mouse strains, pharmacology & pharmacodynamic studies, use of PDX and CDX (sub-cutaneous, tail vein, intra-cardiac & intra-tibial injections), irradiation & bone marrow transplants, drug administration (intra-tumor, intra-peritoneal, gavage), in vivo bioimaging system (IVIS), animal necropsy and tissue isolation, bone marrow extraction & cell isolation, non-GLP and GLP toxicologic evaluation of drugs.• In Vitro Biology: Multi-color Flow Cytometry and cell sorting, tissue culture, ELISA & cell cycle assays, MSD & cytokine assays, cell viability & apoptosis assays, potency, persistence and sensitivity assays, immunofluorescence, DNA & RNA extraction, RT-qPCR and ddPCR, single cell RNAseq, luciferase reporter assays, protein extraction and analysis.Languages: Italian (native), English (fluent), Spanish (fluent), Swedish (conversational)- US & Italian CitizenCell & Gene Therapy Drug Development Immuno-Oncology Pharmacology Toxicology Tumor Biology Cancer Research Immunology In Vivo Translational Assay Development

Experience

1. Principal Scientist, Preclinical & Translational Biology

   Vor Bio

   Jul 2024 — Present · Boston, MA, US

   Research and Translational Biology Lead for VBP301 Phase I clinical trial studying VCAR33, a CD33-targeted CAR-T cell therapy derived from allogeneic healthy donors- Led internal and external efforts for assay development, validation, and qualification for the generation of translational data to assess endpoints in ongoing Phase I VCAR33 clinical trials- Collaborated cross-functionally to develop translational study plans for Phase I and Phase trials- Managed nonclinical and translational data generation at Contract Research Organizations (CROs), implementing comprehensive quality control processes, and promptly addressing data quality and reporting issues when needed- Performed data analysis and effectively communicated translational findings to both internal and external stakeholders- Participated in development of content for abstracts, posters, and regulatory submissions- Managed a team of four, including PhD-level scientists; mentored and trained team members on translational data analysis, interpretation, and QC

Education

• University of Camerino

  Master of Science - MS, Biomolecular Sciences

  2004 — 2006

• Universidad Autónoma de Madrid

  Doctor of Philosophy (PhD), Biochemistry and Molecular Biology

  2008 — 2012

• University of Camerino

  Bachelor's degree, Biology/Biological Sciences, General

  2000 — 2004

Skills

• Microscopy
• Cell Biology
• Biotechnology
• Dna Extraction
• Research Design
• Teamwork
• Science
• Molecular Biology
• Fluorescence Microscopy
• Confocal Microscopy
• Life Sciences
• Transgenic Mice
• Research
• Western Blotting
• Project Management
• Biochemistry
• Microsoft Office
• Laboratory Skills
• Pcr
• Tissue Culture
• Polymerase Chain Reaction (Pcr)
• Genetics
• Immunoprecipitation
• Immunohistochemistry
• Qpcr
• Gel Electrophoresis
• Biology
• In Vivo
• Cell Culture
• Scientific Writing
• Scientific Communications
• Real-Time Polymerase Chain Reaction (Qpcr)
• Microbiology
• Cancer
• Microsoft Word
• Dna
• Molecular Genetics
• Powerpoint
• Microsoft Excel
• Cancer Research