Geoffrey Smith

WORK HISTORY

EDUCATION

SKILLS

ABOUT GEOFFREY SMITH

Principal Scientist and Founding Scientific Lead at Boltz PBC, bridging 10+ years of medicinal chemistry expertise with AI-driven drug discovery to build the next generation of protein-ligand cofolding technology into real-world drug discovery workflows, informed by direct early adoption of cofolding during active project leadershipScientific experience spans multiple target and structural classes including GPCRs, kinases, transcription factors, and nuclear hormone receptors, with additional expertise in BRo5 and GI-restricted drug design. A strong advocate for FBDD, SBDD and AIDD strategies that accelerate project progression and reduce cycle times.At Boltz PBC, I lead scientific validation, customer success, and platform development for the BoltzLab platform - working directly with academic, pharmaceutical and biotech partners to ensure BoltzLab predictions deliver genuine drug discovery success. As the founding lead within the small molecule research team, we translate cutting-edge cofolding science into accessible, impactful tools for the broader discovery community.Previous experience includes leading oncology drug discovery projects at CHARMTx, medicinal chemistry programmes at Sosei Heptares on GPCR alliance projects through H2L and LO stages, oncology target work at CRUK Therapeutic Discovery Laboratories and Charles River Discovery. Academic background: Organic Chemistry PhD, Queen Mary University of London (Bray Research Group, CASE Award sponsored by Syngenta). MSci Chemistry, University of Nottingham.Core expertise: SBDD · FBDD · AIDD · GPCR Drug Design · Hit-to-Lead & Lead Optimisation · Cofolding Platform Validation · Alliance & CRO Management · Digital Chemistry Team Leadership