Gary Yiu
Principal Scientist @Repertoire Immune Medicines
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WORK HISTORY
Principal Scientist @Repertoire Immune Medicines
Cambridge, MA, US
Lead the Antigen Processing and Presentation team to establish cellular platforms of antigen presentation. Over 50 specific antigen presenting cell lines, each expresses high level of a single HLA class I or class II proteins, were generated and validated by immunofluorescent staining and flow cytometry analysis. These cells with monoallelic HLA expression were crucial for the discovery and validation of specific HLA-restricted peptide epitopes of selected antigens in cancer and autoimmune diseases for the development of T cell therapy• Collaborate with multiple in-house functional teams and bioinformatics group to create a database of the identified HLA-restricted peptides • Supervise the design of tandem minigenes (TMGs) or full-length proteins to identify the peptide epitopes of selected antigens presented by antigen presenting cells expressing the monoallelic HLA of interest• Experienced in the isolation of primary immune cells and their stimulation and expansion into dendritic cells and peptide epitope-specific T cells• Coordinate the collaborative efforts across the Repertoire organization to functionally validate the TCRs identified by Repertoire’s proprietary DECODETM platform for various diseases • Team Lead for cell line generation and the development of multiple cell-based assays critical for proof-of-concept and MOA studies• Established collaborations with academic institutions for the studies of antigen presentation• Supervise and manage the research of junior scientists, setting objectives and managing deliverables and professional development
EDUCATION
The Chinese University of Hong Kong
B.Sc. (Hons.), Biology & Biochemistry
Tufts University
Doctor of Philosophy (Ph.D.), Cell & Molecular Biology
The Chinese University of Hong Kong
M.Phil., Anatomical and Cellular Pathology
SKILLS
ABOUT GARY YIU
Innovative and accomplished scientific leader with 13 years of R&D experience in therapeutic and pharmaceutical industry. Trained at Harvard Medical School and have expertise in cancer biology, rare diseases and discovery immunology. Spearheaded internal and external collaborations and excellent in project management and strategic leadership. Experienced and proficient in leading research projects in cancer biology, protein engineering, functional assay development, PD marker discovery, and T cell therapy. Proven ability to generate cell lines for developing cell-based assays to identify and validate potential targets for drug discovery. With track record of success in producing therapeutic proteins from construct design, cell line generation, to protein production. Strong technical proficiency in studying gene expression, signal transduction, HLA-specific antigen presentation, TCR-antigen interactions, and cell-based model development. Published 16 peer-reviewed research papers in high-impact biomedical journals and 15 research abstracts in major scientific meetings. Excellent written, verbal communication and organizational skills.@ My career goal is to use cutting-edge approaches and technologies in immunology, cell biology and molecular biology to study human immune response, gene expression and signal transduction pathways for the development of effective diagnostic tools and medicine for human diseases.Specialties:Cell & Molecular BiologyCell CultureOncologyRare diseasesImmunologyTCR-antigen interactionRecombinant TCR expressionAntigen presentationAdoptive cell therapySignal transductionProtein engineeringProtein ProductionAssay development
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