Gabriel Benton
Scientist Iii, Clinical Pharmacodynamic Biomarkers Program @Frederick National Laboratory for Cancer Research
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WORK HISTORY
Scientist Iii, Clinical Pharmacodynamic Biomarkers Program @Frederick National Laboratory for Cancer Research
US
Lead a team to expand reagent and control support for clinical pharmacodynamic (PD) biomarker studies.• Develop and implement techniques for analysis of immunohistochemistry and immunofluorescence to identify optimal antibody clones and assay conditions for immuno-oncology PD biomarker studies.• Spearhead a project to measure binding kinetics for antibodies with proteins and peptides using surface plasmon resonance.• Collaborate across multidisciplinary teams to troubleshoot reagent and control performance deficiencies related to biological variability, process optimization, purity, and stability.• Conduct extensive in vitro techniques to validate antibody specificity and sensitivity and to establish biologically relevant control materials.• Mentor junior scientists to provide training to improve experimental design and analysis skills.• Oversee subcontracts for development of recombinant monoclonal antibodies and for immunohistochemistry studies to support reagent development and quality control testing.
EDUCATION
Shepherd University
BS, Biochemistry
Georgetown University School of Medicine
PhD, Biochemistry and Molecular Biology
Georgetown University School of Medicine
MS, Biotechnology
SKILLS
ABOUT GABRIEL BENTON
Senior Scientist with a background in biomedical research, assay development, biological manufacturing, quality control, and project management. Extensive industry experience leading a program that recapitulated extracellular environments for culturing stem cells and organoids and developed strategies to assess structural and functional properties. More recently transitioned to the government contracting environment to apply technical expertise and organizational skills to operationalize a quality program to support the development, validation, and clinical implementation of critical reagents and controls to measure pharmacodynamic biomarkers.
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