Florian Laforets
Postdoctoral Researcher @Barts Cancer Institute Queen Mary University Of London
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WORK HISTORY
Postdoctoral Researcher @Barts Cancer Institute Queen Mary University Of London
London, GB
Exploiting extracellular matrix-dependent mechanisms of resistance to chemotherapy in high grade serous ovarian cancer to discover new therapeutic targets. We compared the dynamic response of two ovarian cancer mouse models with different sensitivities to chemotherapy and integrated data obtained at multiple time points both at the transcriptomic (RNAseq) and protein (histology, ECM structure) levels. Our strategy allowed us to highlight vulnerabilities in the tumour extracellular matrix of resistant tumours.Characterised the movement of macrophages and T cells in ex vivo tumour slices of mouse and human ovarian cancer. Designed a semi-supervised R based computational method to analyse cell behaviour and distinguish migrating cells from wobbling cells.
EDUCATION
Université Claude Bernard Lyon 1
Doctor of Philosophy (Ph.D.), Biochemistry and Molecular Biology
Université Claude Bernard Lyon 1
Bachelor of Science (B.Sc.), Biochemistry
University of Leicester
Master of Science (M.Sc.) - 1, Genetics and Biology of the Cell
Université Claude Bernard Lyon 1
Master of Science (M.Sc.) 2 - Research, Genetics, Cellular Biology and Pathologies
Lycée la Martinère Duchère
Baccalauréat, Science - Biology and Geology - specialised in Physics and Chemistry
ABOUT FLORIAN LAFORETS
Scientific Research has always fascinated me and there’s a single reason for it: It is…
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