Eric Burguiere

WORK HISTORY

EDUCATION

SKILLS

ABOUT ERIC BURGUIERE

I am leading the \"Neurophysiology of Repetitive Behaviors (aka NERB) research group at the Paris Brain institute (https://nerb.team/). We have developped a transversal approach using animal models in complement with clinical work. I have been trained as a neurophysiologist specialized in behavior, neuronal recording and chemo/optogenetic approaches with rodent models. Along my scientific career I specialized in developing innovative paradigms to study behavioural adaptation and regulation. I studied mouse models of disorders of motor and cognitive functions. Importantly, I became an expert in pathophysiology of repetitive behaviors, notably with some recent work on compulsive behaviors of a mouse model of OCD-spectrum disorder (Burguière et al, Science 2013). Recently, I developed with my research group some innovative approaches that we can modulate specific brain activities in a closed-loop design, either at rest or within a task (Mondragon*, Schreiweis*, Burguière; Nat Neuroscience, 2024). We developed innovative operant chambers where mice are performing complex cognitive tasks while their social, circadian and cognitive behaviours are monitored automatically and continuously using multiple sensors (Benzina et al, 2021). Some Recent Publications SL Mondragon-Gonzalez, C Schreiweis, E Burguière Closed-loop recruitment of striatal parvalbumin interneurons prevents the onset of compulsive behaviors. Nat Neurosci (2024) Benzina, N, N’Diaye, K, Pelissolo, A, Mallet, L, Burguière, E. A cross-species assessment of behavioral flexibility in compulsive disorders. Commun Biol 4, 96 (2021). E. Burguière, P. Monteiro, L. Mallet, G. Feng, and A.M. Graybiel Striatal circuits, habits, and implications for obsessive-compulsive disorder Curr Opin Neurobiol.(2015) Feb; 0: 59–65. E. Burguière, P. Monteiro, G. Feng, AM. Graybiel. Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors. Science.(2013) Jun 7;34•••37):1243-6. Full List of publications: & hl=fr & oi=ao Prizes 2007 Prize attributed by French Neuroscience Society for the best Neuroscience Thesis of the year. 2005 Prize attributed by Lilly Institute for the PhD work accomplished. Present Scientific Collaborations Since 2009 Pr. Ann Graybiel and Pr. G. Feng (MIT, Cambridge, USA) Since 2014 Pr. Rui Costa (Champallimaud Institute, Lisbon, Portugal) Since 2019 Pr. Wolfgang Enard (Munich University, Germany)