D. Elshan Nakath G. Ralalage
Associate Director - Medicinal Chemistry @Calibr-Skaggs Institute For Innovative Medicines
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WORK HISTORY
Associate Director - Medicinal Chemistry @Calibr-Skaggs Institute For Innovative Medicines
San Diego, CA, US
Continued leadership in the antiviral programs of the institute, engaging collaborative teams to progress protease inhibitor programs to clinical candidate stage• Vaccine adjuvant (across multiple immune pathways: TLR 4/7/8/9, STING, and other novel pathways) discovery and development, from high-throughput screening up to pivotal NHP studies• Established extensive in-house formulation development and solid/suspension characterization capabilities• antibody-drug conjugate (ADC) development, focusing on solubility, stability, and conjugation efficiency of payload-linker derivatives.• Novel Program development for neurodegenerative (CNS) diseases and blood disorders, including collaborative design of in vitro/in vivo models, and medicinal chemistry.• Contributed to expansion of in-house screening libraries, and automated QC processes.
EDUCATION
UCLA
Postdoctoral Scholar, Medicinal and Pharmaceutical Chemistry
University of Arizona
Doctor of Philosophy (Ph.D.), Chemistry
University of Colombo
Bachelor of Science (B.Sc.), Chemistry
SKILLS
ABOUT D. ELSHAN NAKATH G. RALALAGE
Ph.D. in Chemistry, experienced in leading and managing chemistry teams (internal and CRO/CMO) in multiple drug development projects (oncology, antivirals, regenerative medicine, vaccine adjuvants, CNS programs, antibody-drug conjugates (ADC), blood disorders)- to progress projects from SAR optimization to the clinic. • 10+ years of experience in pharmaceutical development, with expertise in Medicinal and Organic Chemistries, with a proven track record of progressing (H2L, LO, IND-enabling) hit compounds to the clinic • 16+ years of experience in highly collaborative/integrated medicinal chemistry research, with leadership skills in coordinating teams of different research disciplines to deliver results with accuracy, accountability and timeliness.• Self-motivated & energetic chemist well versed in biological assessment of potential therapeutics, with work leading to patent inventorship (6) and peer-reviewed scientific publications (7 first-author).
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