Rohit Chakravarty

About Rohit Chakravarty

Group Leader in Chemical Research department. 16 years of relevant industry experience with companies like Sun Pharma, Jubilant Pharmova, Ranbaxy. Development of cost effective and innovative technologies for API and transforming batch process to continuous Flow process using Corning G-1 AFR, Coflore ACR, Vapourtec, Fixed bed reactor and various tubular reactors.Demonstrating lab and plant scale flow chemistry for Ammonolysis, Lithiation, Reduction using DIBAL-H, Nitration, C-C arylation and Hydrogenation reaction using Pd/C, Raney Nickel in continuous flow.Nucleophilic substitution reaction, Ammonolysis in CSTR cascade.Expertise in handling Pyrophoric reagents n-Butyl Lithium, DIBAL-H in continuous Flow reactors for synthesis on gram to kilogram scale using Corning G1 and PFR.Implementing novel methodologies in API\'s for developing new route using flow chemistry. Identification of various schemes available for the molecule, carrying out feasibility studies, process optimization, validation and scale up. Synthesizing molecules and scale up to gram scale to generate spectroscopic data for patent filing. Exhibit plant production of APIs for DMF filing meeting regulatory requirement. Time bound delivery of target drug molecule. Conducting of polymorphic studies on APIs, studying physicochemical properties of polymorphs. Participation in the group discussion and to give new ideas with the help of literature search.a)Expertise in multistep organic Synthesis. b) Adequate knowledge of various purification techniques like crystallization, extraction, fractional distillation, salt preparation. c) Adequate knowledge of cGMP, GLP, ICH guidelines and developing the products as per regulatory norms. d) Well versed with polymorphism of final APIs and different techniques for preparation of new polymorphs. Expert at their analysis using thermo-gravimetric techniques and XRD.

Experience

1. Research Manager (Flow Chemistry and Process Development)

   SUN PHARMA

   Oct 2022 — Present · Gurugram, IN

   Involved in transforming batch process to continuous Flow process using Corning G-1 AFR, Coflore ACR, Vapourtec, Fixed bed reactor and various tubular reactors.Demonstrating lab and plant scale flow chemistry for Ammonolysis, Lithiation, Reduction using DIBAL-H, Nitration, C-C arylation and Hydrogenation reaction using Pd/C, Raney Nickel in continuous flow.Nucleophilic substitution reaction, Ammonolysis in CSTR cascade.Expertise in handling Pyrophoric reagents n-Butyl Lithium, DIBAL-H in continuous Flow reactors for synthesis on gram to kilogram scale using Corning G1 and PFR.Implementing novel methodologies in API\'s for developing new route using flow chemistry.

Education

• Chaudhary Charan Singh University

  M.sc, Chemistry

  2004 — 2006

• NALSAR

  PG Diploma in Patent Laws, Patent Laws

  2012 — 2013

• CSIR National Chemical Laboratory Pune

  Industrial training on Continuous Flow synthesis, Continuous Flow Synthesis

• Jubilant Life sciences

  Lean Six Sigma Green Belt Certificate, Six sigma Quality improvement technique

  2018 — 2019