Muthuraju Sangu

About Muthuraju Sangu

My doctorate thesis research was concerning high altitude physiology mainly focusing on memory functions. Stimulation chamber used for inducing hypobaric hypoxia. Animal handling, animal behavior analysis, basic neurotoxicity and neurochemical studies were carried out during the doctorate research. Then moved to University of Turin, Italy where I was focusing on nociceptive pathways and neurotrophic factors using p8-p12 neonatal mice. This study used glial cell derived neurotrophic factors (GDNF) as a molecule to examine the role of analgesic effect. After that I joined in the Department of Neurosciences, School of Medical Sciences, University of Sains Malaysia (USM) in Malaysia. This study was aimed to understand the effect of Normobaric hyperoxia (100% O2) on closed traumatic brain injury in the basal ganglia of mouse models. The stereotactic surgery coordinates at basal ganglia, fluid percussion device for induction of closed brain injury, IntelliCage as automated behavior system, morphology, locomotor behaviors. Another offer I got from the Department of Neuropsychopharmacology, University of Sao Paulo, Brazil. The main theme of this laboratory is to understand the fear and anxiety behavior mediated by antipsychotic drugs through different brain regions. Finally, joined as a senior lecturer (equivalent to the rank of Associate Professor in North American Universities) in the department of Neuroscience, Universiti Sains Malaysia (USM), Malaysia. Based on my expertise, I established a project on stress neurobiology and alcohol addictive behavior in a mouse model. Also, I was working as a Co-investigator for other projects dealing with intracerebellar hemorrhage mouse model, effect of hypoxia on Semaphorin family in human hippocampal astrocytes, effects of Centella asitica on learning and memory, effects of Tualang honey supplement on memory performance and human TB project. Again, I was offered a post-doctoral position in the College of Pharmacy, University of Houston to study the role of presynaptic proteins in alcohol addiction. Currently, I have been working as an Instructor in Radiology, Houston Methodist Research Institute to study the neuroinflammatory markers in the various neurological disorders using PET/MRI imaging in mice and humans. Also, I am involved in a clinical trial for 18F-SMBT-1 in healthy and Alzheimer’s disease patients. On the other hand, I am working on a NASH mice model using PET/MRI using PET tracer for liver cancer.

Experience

1. Instructor in Radiology, Hmai

   Houston Methodist

   Sep 2022 — Present · Houston, TX, US

Education

• Jamal Mohamed College, Tiruchirappalli - 620 020.

  Master of Philosophy - MPhil, Neurobiology and Behavior

  2003 — 2004

• Bharathiar University

  Doctor of Philosophy - PhD, Neurobiology and Behavior

  2004 — 2008

• Madurai Kamaraj University

  Master of Science - MS, Biotechnology

  2001 — 2003