Karthika Chenmala

About Karthika Chenmala

AboutI am a translational pharmacology scientist with extensive experience spanning drug discovery, PK/PD modeling, in vivo pharmacology, formulation science, and IND-enabling research, currently serving as a Postdoctoral Associate at Weill Cornell Medicine with prior training at the National Institutes of Health (NIA, NIH).My research bridges mechanistic biology and human-relevant preclinical models, with a strong focus on translating scientific insights into clinically actionable therapies. At Weill Cornell, I lead PK/PD profiling and preclinical development of non-hormonal male contraceptives, collaborating with industry partners to advance orally available small-molecule candidates through formulation, stability, toxicity, and efficacy studies.I bring deep expertise in multi-species pharmacokinetics (mouse, humanized mouse, rabbit), IV/IP/oral dosing, drug–drug interaction studies, and exposure–response modeling, using platforms such as Certara Phoenix, SimCYP, GastroPlus, and ADMET tools. My work includes artificial insemination and reproductive efficacy models, an uncommon and highly specialized skill set in translational drug development.Previously at NIH, my research focused on aging biology, genomic stability, senescence, and DNA repair, where I conducted extensive in vivo and molecular studies under IACUC and GLP-aligned environments. I have been recognized with the NIA Director’s Award for DEIA leadership (2024).With 16+ first-author publications, book editor roles, 867+ citations, and experience reviewing over 100 scientific articles, I bring both scientific depth and leadership to interdisciplinary teams across academia and industry. Core Expertise:Translational Pharmacology | PK/PD & DMPK | In Vivo Models | IND-Enabling Studies | Drug Discovery | Formulation & Drug Delivery | ADMET | Molecular Biology | Regulatory-Aligned Research Career Interests:Industry R&D, Translational Science, PK/PD, Preclinical Development, Drug Discovery, and Regulatory-Aligned Research Roles

Experience

1. Postdoctoral Associate

   Weill Cornell Medicine

   Apr 2025 — Present · NY, US

   Led PK/PD profiling of second-generation soluble adenylyl cyclase (sAC) inhibitors for non-hormonal male contraceptives; conducted IV and oral dosing studies in mice and rabbits.• Validated 8HUM humanized mouse model for predictive human PK and CYP-mediated metabolism.• Executed artificial insemination studies in hyperovulated mice to assess contraceptive efficacy, integrating molecular and translational insights.• Directed cross-functional teams for mechanistic studies of sAC in sperm function, incorporating molecular biology, ADMET modeling, and pharmacology.

Education

• Grace collge of pharmacy

  Bachelor's degree, Pharmacy

• JSS Medical College

  Master of Pharmacy, Pharmaceutical Sciences

• JSS Medical College

  Doctor of Philosophy - PhD, Pharmaceutical Sciences

• JSS Medical College, Mysore

  Doctor of Philosophy - PhD, Pharmaceutical Sciences