Damodhar M. Ghime

About Damodhar M. Ghime

I am a multidisciplinary R&D scientist with a PhD in Chemical Engineering and strong experience (> 4.5 years) in developing cutting-edge diagnostic technologies, particularly electrochemical biosensors for IVD applications. My expertise bridges multiple domains—including assay chemistry, oligonucleotide synthesis, catalyst development, nanocomposite fabrication for antifouling interfaces, and electrochemical sensing platforms such as e-ELISA.Currently, I am engaged in IVD assay development and electrochemical biosensor design, with a strong focus on CLSI-aligned reagent stability studies (EP-25-A2), solid-phase DNA/RNA oligo synthesis, and integration of nanomaterials for improving sensor performance. My academic background includes advanced oxidation process (AOP) development for industrial wastewater remediation—showcasing my versatility from environmental to diagnostic applications.I am passionate about solving complex scientific problems through structured experimentation, data analysis, and collaboration. My work is driven by curiosity, innovation, and a desire to translate chemical and biological knowledge into real-world technologies that improve healthcare outcomes.Core Interests: IVD assay development, electrochemical diagnostics, molecular sensing platforms, reagent stability design (CLSI EP-25-A2), nucleic acid chemistry, nanomaterials for biosensors, AOPs, catalyst/enzymatic substrate synthesis, translational R&D.Key Skills: Experimental planning, scientific writing, data analysis, troubleshooting, protocol development, cross-functional collaboration, patience, determination, analytical thinking, adaptability, and effective communication.

Experience

1. Research Scientist

   Technoculture Research

   Jul 2025 — Present · Bodh Gaya, IN

   Led the ideation and development of innovative assay concepts- including half-antibody generation, HRP-mimetic systems, and antibody transfer from magnetic beads to electrode surfaces- and contributed to finalizing their provisional filings. Worked on the conceptualization and early validation of self-immolative electrochemical redox substrates for enzyme-triggered signal generation, contributing to new assay formats for diagnostic applications. Developing multiplexed electrochemical detection assays using molecular beacons and hybridization strategies on gold (Au) electrode arrays. Worked on ideation and early-stage development of an electrochemical alcohol-to-jet-fuel process, generating a technical concept and implementation road-map for potential scale-up. Prepared regulatory documentation for submission of test and manufacturing license applications to CDSCO, and QMS including- Plant layout - Cartridge manufacturing flowchart - SOP and work instructions (WIs) for cartridge assembly procedure - Quality Plan.

Education

• Laxminarayan Innovation Technological University

  Bachelor's degree, Polymer/Plastics Engineering

• National Institute of Technology Raipur

  Doctor of Philosophy - PhD, Chemical Engineering

• National Institute of Technology Raipur

  Master of Technology - MTech, Chemical Engineering