Domenico Lazzaro

WORK HISTORY

EDUCATION

ABOUT DOMENICO LAZZARO

Domenico Lazzaro is an M.D. Pathologist with academic experience. At present he is working as consultant pathologist in Roche EBDO department (Eearly Biomarker Discovery Oncology) in Digital Pathology Team; he Is Based in Basel He was Professor of Cancer Ultrastructural Pathology at The University of” Tor Vergata “1984-86 (Rome -Italy) and recently (20••••13) he was contract professor of immunopathology in the Department of Public Health 4th University of Rome “Foro Italico” (Rome-Italy). Dr. Lazzaro holds a Ph.D. in Experimental Medicine & Molecular Pathology. Dr. Lazzaro established his experience in molecular biology working for almost 4 years (19••••94) at the EMBL (European Molecular Biology Laboratory) headquarter Heidelberg, Germany. He spent long years working in the field of Molecular Biology and molecular pathology as part of the Merck Research Laboratories (MRL)/Merck & Co. He was leading a group of molecular pathology for “in vivo”drug efficacy study that was part of the Merck Oncology franchise worldwide for 16 years. He developped mouse models to test cancer vaccine efficacy for human therapy as well as to test the efficacy of antitumoral small molecules, therapeutic Antibodies and to determine the possible correlation between vaccination and/or small molecule effect on cancer stem cell. He developed Immunohistochemestry (IHC) based Companion diagnostics (Cdx) for cancer targeted therapy- PARP Inhibitor Program MK487 (Poly (ADP-ribose) polymerase (PARP) inhibitor)- ClinicalTrials.gov Identifier : NCT00••••02. International patents: 1) Obesity CNTF therapy PATENT USA May 20,2003 Appl. No: 308368 Merck & Co. 2)Cancer Vaccine based on the Matrix Metalloproteinase-11 PATENT APPLICATION USA 2007 Patent Application ITR0108 Serial Number No. 60/724,498 Merck & Co.