Desmond Chin
Principal Scientist @Novo Nordisk
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WORK HISTORY
Principal Scientist @Novo Nordisk
Boston, MA, US
Built and led translational teams supporting multiple programs: designed and qualified PD, target engagement, and exploratory biomarker assays across murine/NHP models and clinical samples, encompassing matrix stability, interference testing, and multi-species qualification.Led biomarker strategies for multiple programs in diabetes and rare blood diseases, with biomarkers spanning target engagement, proof-of-mechanism/concept, and exploratory biomarkers across discovery through Phase 2.Developed precision medicine hypotheses by mining large-cohort datasets (UK Biobank) and registered clinical trials to identify predictive biomarkers enabling patient subpopulation enrichment strategies.Established feasibility of bioimaging biomarkers (dopamine PET, MRI, electroencephalogram) as Go/No-Go decision criteria for Phase 1; integrated imaging readouts to derisk target and candidate selection.Shaped Phase 1 clinical trial design by integrating PKPD modeling to inform initial dose/frequency and propose biomarker-driven decision-guiding framework in collaboration with Clinical Pharmacology and Biostatistics.Served as translational lead for a Phase 2 trial in lower-risk MDS (NCT05••••25): designed the full exploratory biomarker plan, directed CRO oversight, qualified molecular assays, compiled central lab manuals, and presented interim findings to the Medical Director and at cross-functional global science meetings.(manuscript in preparation)
EDUCATION
Nanyang Technological University Singapore
Bachelor of Science (BSc) Biological Science, Biology, General
National University of Singapore
Doctor of Philosophy (PhD), Cancer Biology
SKILLS
ABOUT DESMOND CHIN
10 years of experience in drug development spanning multiple disease indications such as hemoglobinopathies, cardiometabolic diseases, oncology, and bleeding disorders. Experienced translational science leader in biomarker strategy and executions for programs from ranging from target validation to phase I clinical trials, and product lifecycle management.3. Effective manager who has successfully led internal cross-functional teams and managed external CROs to achieve company goals.
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