Debabrata Mandal

Associate Professor @Department Of Biotechnology, Niper Hajipur

Bihar, IN

My research area involves drug delivery against neglected tropical diseases (NTDs) like leishmaniasis using nanoparticles. Further, drug delivery against drug-resistant fungal and bacterial infections using quantam dot are also explored. Delivery of drugs followed by identification of mechanism of action using biochemical, molecular biology and proteomics approach is the area of our expertise. Generation of recombinant proteins, enzyme assay and drug binding interactions with ITC and CD are done to quantify the drug-target binding interactions. In our recent work, we have identified natural compounds like medium chain fatty acids (caprylic acid), flavonoids (7, 8-dihydroxyflavone) etc. as key antiparasitic agents. The ergosterol biosynthesis and polyamine biosynthesis pathway of parasite was found to be the key target for these antileishmanial agents. In another work, we are exploring antibiotic synthesized quantam dots as antimicrobials for multi-drug resistant bacteria with possible mechanism of action. Identification of cheap but effective natural compounds, biomaterials for drug development against NTDs and antimicrobial resistance (AMR) will be our future plan