David Wiley
Associate Director at Life Edit Therapeutics
- Role
- Associate Director at Life Edit Therapeutics
- Location
- Durham, NC, US
- LinkedIn followers
- 500 followers
About David Wiley
In-depth understanding of RNA, hematology, oncology, and expertise in several monogenic…
Experience
Associate Director
Oct 2022 — Present · Durham, NC, US
Manage a team of 8+ scientists focused on the production and engineering of mRNA and guide RNA-Led the development and optimization of guide RNA and mRNA chemical and sequence engineering, achieving over a 3x improvement in in vivo editing efficiency-Oversee two mRNA production processes: a high-throughput process that generates over mRNA molecules per month, critical to the company’s screening pipeline, and a robust large-scale production process successfully utilized in an NHP study-Developed a lentiviral pooled screening platform that has significantly impacted guide engineering and off-target assessment-Collaborated closely with the CMC group to evaluate GMP manufacturing capabilities of potential vendors for mRNA and guide RNA.
Skills
- Developmental Biology
- Genetics
- Molecular Cloning
- Stem Cell Research
- Cell Culture
- Cell Biology
- Embryology
- Zebrafish
- Compound Screening
- Molecular Biology
- Confocal Microscopy
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