David Schenk

About David Schenk

Nineteen years of pharmaceutical and industrial experience with nine years of experience as a supervisor.• Expertise in many analytical techniques including: NMR, LC/MS/MS, ICP, FTIR, HPLC, GC/MS, particle size analysis TG, UV, radiochemical detection and wet chemical methods.• Expertise in synthesis, radiochemistry, metabolism, phytoalexin elicitation, and enzyme mechanisms and compound/metabolite isolation from biological sources.• Broad knowledge background including production scale chromatography, and pharmacology. • Experience Release Testing GMP API batches and supporting CMC document writing for ADME studies.• Experience performing 100mg to multi-kg chemical separations utilizing SFC, HPLC and Flash.

Experience

1. Associate Principle Scientist- Analytical Chemistry, Process Research-lateral Move

   Merck

   Mar 2015 — Present · Rahway, NJ, US

   Provides Analytical support including HPLC and GC method development for Merck Process Chemists and Engineers. 20••••21 Board member on North Jersey Mass Spectrometry Discussion Group.20••••18 North American Regional Trustee, International Isotope SocietyThe Analytical Method Development and Validation Approach Employed after Identification of 2-bromi-5-chlorobenzaldehyde as a Solvent-dependent, radical and UV-induced Impurity Produced from an Imine Intermediate; poster EAS 2016Determining the isotopic abundance of a labeled compound by mass spectrometry and how correcting for natural abundance distribution using analogous data from the unlabeled compound leads to a systematic error, David J. Schenk*, William J. S. Lockley, Charles S. Elmore, Dave Hesk, Drew Roberts. J Labelled Compounds and Radiopharmaceuticals DOI: 10.1002/jlcr.3370 online Feb 2016; also best poster at IIS 2015.Enzymatic approach towards the synthesis of isotopically labeled (R)-9-(2-hydroxypropyl)adenine, Nelo R. Rivera, Jeffrey Moore, David J. Schenk, Heather Wang, David Hesk, Ingrid Mergelsberg, Tet. Lett, Feb 2016NMR-based approach to the analysis of radiopharmaceuticals: radiochemical purity, specific activity, and radioactive concentration values by proton and tritium NMR spectroscopy, D.J. Schenk, P.G. Dormer, D. Hesk, S.R. Pollack, C. Flader Lacey, J. Label. Compd. Radiopharm Doi: 10.1002/jlcr.3295Site selective syntheses of [3H]omeprazole using hydrogen isotope exchange chemistry, Scott R. Pollack and David J. Schenk, J. Label. Compd. Radiopharm Doi: 10.1002/jlcr.Discovery of 6-(fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)Abbas M. Walji, Eric D. Hostetler, Et al, J Med Chem onlineDetermination of tritium atom location and distribution using tandem mass spectrometry, T. Pereira, D.J. Schenk, Et al. oral presentation, IIS

Education

• University of Illinois Urbana-Champaign

  PHD, Chemistry

  1995 — 2000

• BlackHawk College moline IL

  Associate's degree, Chemistry

  1986 — 1989

• Iowa State University

  BS, chemistry

  1989 — 1991

Skills

• Nmr Spectroscopy
• Uv
• Ftir
• Pharmaceutical Industry
• Sop
• Pharmacokinetics
• Uv/Vis
• Gc-Ms
• Assay Development
• Organic Chemistry
• Hplc
• Chromatography
• Lead Change
• Research
• Adme
• Gas Chromatography
• Biotechnology
• Purification
• High-Performance Liquid Chromatography (Hplc)
• Gmp
• Clinical Development
• Nmr
• Validation
• Mass Spectrometry
• Medicinal Chemistry
• Laboratory
• Drug Development
• Bioanalysis
• Liquid Chromatography-Mass Spectrometry (Lc-Ms)
• Biochemistry
• Drug Metabolism
• R
• Wet Chemistry
• Lc-Ms
• Lims
• Pharmacology
• Pharmaceutics
• Drug Discovery
• Organic Synthesis
• Synthetic Organic Chemistry