David Loczenski
Programme Lead @Istesso
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WORK HISTORY
Programme Lead @Istesso
Led IND-enabling preclinical programmes for early-stage drug candidates in a virtual biotech company.• Designed and executed preclinical development plans across biology, ADME/DMPK, safety pharmacology, toxicology, and CMC (small molecule).• Managed budgets of €3+ million; negotiated and oversaw work with 16 CROs and 14 consultants.• Led experimental biology studies for mode-of-action insight into immunometabolism, fibrosis, and adaptive repair mechanisms; including in vitro and in vivo preclinical models.• Led translational target engagement biomarker strategy, utilising in vitro and in vivo models, transcriptomics and clinical sample biomarker validation.• Implemented “fail fast” strategies to optimize pipeline progression.• Ensured GLP compliance of critical studies and supported writing of regulatory documents.
EDUCATION
Nottingham Trent University
Bachelor's Degree, Sport and Exercise Science
University of Nottingham
Doctor of Philosophy - PhD, Molecular Biology
ABOUT DAVID LOCZENSKI
Strategic and hands-on drug development professional with 10+ years of experience leading…
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