David Glass

About David Glass

I am a systems immunologist with expertise in B and T cell biology, and my research has advanced understanding of human immunity across diverse disease contexts.I became an immunologist so that I could spend my life making discoveries that improve people’s health. I firmly believe that a deep understanding of the human immune system is crucial for preventing and treating human diseases. Throughout my career, I have leveraged a systems biology approach, encompassing single-cell, spatial, multi-omic, and bioinformatic methodologies, to generate basic and translational insights into human immunity, including the development of both experimental and computational tools. These diverse experiences and skills position me to lead a collaborative and dynamic lab group capable of pursuing wide-ranging questions within human immunology.The first major goal for my future lab is to define the B cell states and signals that enable induction and maintenance of durable immune memory in humans. Rather than focusing on a single disease, we will develop and apply antigen-specific systems biology approaches to investigate B cell function and identity in vaccine responses, infectious disease, cancer, autoimmunity, and other contexts, in collaboration with clinical and research partners. By utilizing primary samples and innovative in vitro human organoid models, we will dissect mechanisms enabling perturbation of B cell fate for clinical translation.Select Publications:Shasha & Glass, et al. “Hallmarks of antigen experience and terminal exhaustion in T cells are absent in multiple myeloma patients from diagnosis through maintenance therapy,” Blood (2025).Glass, et al. “Multi-omic profiling reveals the endogenous and neoplastic responses to immunotherapies in cutaneous T cell lymphoma, “ Cell Reports Medicine (2024).Glass & Tsai, et al. “An integrated multi-omic single cell atlas of human B cell identity,” Immunity (2020).Tsai & Glass, et al. “Multiplexed single cell morphometry for hematopathology diagnostics,” Nature Medicine (2020).Full publication found on Google Scholar profile, linked below my picture.Select Awards:NIH-NIAID K99/R00 Pathway to Independence Award (20••••30)Fred Hutch Translational Data Science IRC Pilot Award (20••••26)ASH Fellow Scholar Award (20••••26)NIH-NCI Loan Repayment Program (20••••25)CRI Irvington Postdoctoral Fellowship (20••••25)Fred Hutch Mahan Computational Biology Postdoctoral Fellowship (20••••22)Stanford Bio-X Interdisciplinary Graduate Fellowship (20••••21)Stanford Graduate Fellowship (20••••18)

Experience

1. Postdoctoral Researcher

   Fred Hutch

   Apr 2021 — Present · Seattle, WA, US

   Applying systems immunology approaches to interrogate the adaptive immune system in human health and human disease. Leading projects investigating B and T cell responses in vaccination, hematological malignancies, infectious disease, and other contexts.Utilizing multi-omic single-cell sequencing (antigen-specificity, protein, transcriptome, epigenetics, and immune repertoire), high-dimensional cytometry, bulk omics (proteomics, transcriptomics, immune reperotire), spatial proteomics and transcriptomics, and in vitro assays. Developing and applying bioinformatic tools to investigate cellular profiles and identify features enriched in patient cohorts (e.g. responders vs non-responders in immunotherapy).Advised by Evan Newell with co-mentorship from Julie McElrath.

Education

• Stanford University

  Doctor of Philosophy (PhD), Computational and Systems Immunology

  2015 — 2021

• The University of Texas at Austin

  Bachelor of Science (B.S.), Cell and Molecular Biology

  2013 — 2015

• Texas State University

  Bachelor of Music, Sound Recording Technology

  2004 — 2007