Daniel Brogan
Senior Scientist @Arbor Biotechnologies
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WORK HISTORY
Senior Scientist @Arbor Biotechnologies
Cambridge, MA, US
Lead Engineer, Pharma Partnership:Led structure-informed, mechanistic, and ML-drivenengineering for a pharma partnership on an undisclosed technology.Architected an orthogonal input ML approach to protein engineering integratingstandard activity screening assays, biochemical properties, and translational data.Established primary cell validation screening for engineered variants.Established low- and high-throughput cell-based expression and stabilityscreening for variant evaluations.Improved editing activity in primary cells by 2-fold in under 6 months.Mentorship:Guided junior scientist in the implementation and development of stabilityassays, primary cell assays, structure guided design, and applying ML-based engineering.
EDUCATION
Ursinus College
Bachelor of Science - BS, Neuroscience
UC San Diego
Master of Science - MS, Chemistry
UC San Diego
Doctor of Philosophy - PhD, Biochemistry and Molecular Biophysics
ABOUT DANIEL BROGAN
I engineer gene editing systems for therapeutic applications, grounded in first-principles biology and focused on translating platform capabilities into real clinical impact. My work spans protein engineering, indication strategy, and the interface between discovery and development. I aim to build therapies that don’t just work in models, but change disease trajectories in patients.If there is not a cure, we should make one.
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