Christine Nhu Huynh Ho
Process Development Scientist for Downstream Processing @Gritstone Bio
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WORK HISTORY
Process Development Scientist for Downstream Processing @Gritstone Bio
Pleasanton, CA, US
Led and managed tech transfer recommendations for GMP manufacturing processes, including reviewing, planning, and drafting of manufacturing procedures, project implementation plans, manufacturing batch records, technical development reports, and GMP documents.• Conducted drug purification trials using various technologies such as AKTA chromatography, TFF hollow fibers, depth, and sterile filters.• Assisted with upstream cell culturing of HEK293 and final formulation studies.• Collaborated cross functionally with upstream, automation, manufacturing, qualitycontrol, quality assurance, analytical technology, and drug development team.• Designed small-scale process development studies and transferred to large-scaleGMP manufacturing for clinical trials.• Optimized drug product yields and reduced process time by continuouslyimproving drug purification steps.• Performed automated skid purification runs and prepared for Clinical Trial Phase and the IQ, OQ, and PQ runs.• Trained manufacturing associates on the downstream purification automation skid.• Attended biweekly readiness meetings to ensure manufacturing, processdevelopment, and quality are aligned for Phase clinical trials.
EDUCATION
University of Cincinnati
Master of Science - MS, Criminalistics and Criminal Science
University of California, Riverside
Bachelor of Arts - BA, Neuroscience and Psychology
University of Oxford
MSc, Therapeutics
Harvard University
Master's degree
ABOUT CHRISTINE NHU HUYNH HO
With over 10 years of experience in bioprocessing, drug development, and quality, my mission is to apply my scientific knowledge, technical skills, and analytical abilities to support the advancement of novel and innovative therapies that can improve the lives of patients. I have a strong background in experimental and translational therapeutics, biotechnology, and business administration, which enables me to bring diverse perspectives and experiences to the team. In my current role, I conduct drug purification trials using various technologies such as AKTA Avant and Pilot chromatography, TFF hollow fibers and flat sheets, and sterile filters. I also provide tech transfer recommendations for GMP manufacturing processes, including the reviewing, planning, and drafting of manufacturing procedures, project implementation plan, manufacturing batch records, technical development reports, and GMP documents. I have successfully conducted small-scale process development studies and transferred them to large-scale GMP manufacturing for clinical trials. I have also provided subject matter expert knowledge to troubleshoot issues during large-scale GMP manufacturing, and established process qualifications and process performance qualification ranges. I have demonstrated proficiency in using digital marketing channels and product development skills to enhance the communication and collaboration within the organization and with external partners.
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