Chengguo Dong
Director of Medicinal Chemistry
- Role
- Director, Medicinal Chemistry at Protagonist Therapeutics
- Location
- Newark, CA, US
- LinkedIn followers
- 500 followers
About Chengguo Dong
A highly motivated and innovative medicinal chemist; co-inventor of one FDA approved FIC drug and 6 clinical/back-up drug candidates, & 40 issued US patents and journal publications.Collaborated closely with multidisciplinary project teams on various drug discovery programs ranging from enzyme inhibitors to nuclear receptor & GPCR modulators to protein/protein interaction inhibitors.Extensive hands-on experience in both ligand-based and structure-based drug designInvolved targets include Ferroportin, PD-1, Integrins, MALT1, CCR6, Menin-MLL, RORγt, LXR.Experienced in the therapeutic areas: oncology, immuno-oncology, fibrosis, CNS, cardiovascular diseases, autoimmune and inflammatory disorders.• Demonstrated project management and leadership capabilities in an interdisciplinary environment.• Expert knowledge in small molecule and peptide based drug discovery from HTS to DC nomination.• Excellent knowledge of molecular modeling, ligand-based, and structure-based design.• Expertise in IP analysis and assessment, patent drafting, and filing.
Experience
Director, Medicinal Chemistry
Jan 2024 — Present · US
Peptide Drug Discovery: Linear and macrocyclic peptide design; SAR optimization; stabilization strategies (cyclization, stapling, lipidation); ADME/PK-driven optimization; candidate nomination support.
Education
Harvard University
Postdoctoral fellow, Organic Chemistry
The Graduate Center, City University of New York
Doctor of Philosophy (PhD), Chemistry
2001 — 2007
East China University of Science and Technology
Master of Science (MS), Organic Chemistry
1998 — 2001
Skills
- Analytical Chemistry
- High-Performance Liquid Chromatography (Hplc)
- Chromatography
- Nmr
- Mass Spectrometry
- Medicinal Chemistry
- Nuclear Magnetic Resonance (Nmr)
- Chemistry
- Lc-Ms
- Hplc
- Drug Design
- Drug Discovery
- Organic Synthesis
- Organic Chemistry
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