Charles Rotter
Principal Scientist @Rapport Therapeutics
Signup · Get unlimited contacts
WORK HISTORY
Principal Scientist @Rapport Therapeutics
San Diego, CA, US
Responsible for representing the Drug Metabolism and Pharmacokinetics (DMPK) functional area. Provide scientific and strategic input in a matrix environment; oversee DMPK studies to support preclinical and clinical development. Design, execute, and manage PK, PK-PD, and drug metabolism studies, integrating ADME, PK, and PK/PD endpoints to guide optimization strategies.Apply understanding of DMPK, physicochemical properties and biotransformation to support/influence compound design, program progression and strategy.Leverage in-depth knowledge of drug transporters to improve CNS drug candidates’ penetrance across blood-brain barrier.Evaluate and interpret in vitro and in vivo DMPK data to address key program challenges.Implement innovative technologies and approaches to address program uncertainties.
EDUCATION
University of Connecticut
Molecular and Cell Biology
SKILLS
ABOUT CHARLES ROTTER
20+ years of R&D experience focusing in Pharmacokinetics and Drug Metabolism, with emphasis on ADME Technologies and Drug Transporters. Co-authored 25+ publications and 12+ conference presentations.Application of in vitro/in vivo ADME related studies to support discovery and development projects.Investigation of transporter -mediated drug disposition in cancer tissue to facilitate tumor targeting.Specialties: Drug Metabolism and Pharmacokinetics ADME Science Drug Transporters In Vitro - In Vivo Correlation Drug-Drug Interactions Enzymology DMPK High Throughput Screening Drug Discovery & Development Human PK prediction PBPK Program Management Due Diligence IND- enabling
This profile is compiled from publicly available professional sources. Unifers is not affiliated with or endorsed by LinkedIn. Request removal of this profile.