Chaofeng Dai
Senior Research Investigator @Arvinas
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WORK HISTORY
Senior Research Investigator @Arvinas
New Haven, CT, US
Assist in the management of international chemistry CRO services up to 200+ MedChem FTEs, including daily oversight of relevant technical activities• Conduct and oversee process chemistry research to enable modification of Discovery Chemistry routes to provide kilogram quantities of intermediates and APls• Ensure delivery of the required materials into the early development pipeline to meet timelines• Proactively mitigate issues and hurdles to ensure effective process development and scale-up of API processes• Ensure that process and analytical development at external CROs is conducted in a manner to facilitate subsequent scale-up activities in development• Play a key role in chemistry knowledge transfer between Discovery and Process Chemistry
EDUCATION
Lanzhou University
BS, organic chemistry
Xiamen University
Ph. D., organic chemistry
Lanzhou University
M. S, Synthetic Organic Chemistry
SKILLS
ABOUT CHAOFENG DAI
Experienced process chemist with extensive hands on experience on medicinal and analytical chemistry.• Solid background in modern synthetic and mechanistic organic chemistry • Extensive experience in multi-steps synthesis of complex natural products • Phosphoramidite chemistry and solid phase DNA oligo synthesis, purification and post synthesis modifications• Modified nucleoside triphosphate analogues for enzymatic DNA synthesis; • Expertise in bioconjugate chemistry especially for DNA and protein labeling• Good understanding of SAR and expertise in optimizing candidate efficacy• Outstanding skills in compound purification and characterization • Long-lasting leadership experience in large academic and medium industrial teams• Strong ability to multi-task project management skills in academia and CRO industry• Excellent verbal and written communication skills with multi-disciplinary team members
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