Carly Hamel
Rotational Scientist II @ Genentech
- Role
- Scientist Ii at Genentech
- Location
- San Francisco, CA, US
- LinkedIn followers
- 500 followers
About Carly Hamel
I’m a Neuroscience graduate dedicated to advancing medicine through a human-centric lens.…
Experience
Scientist Ii
Aug 2025 — Present · South San Francisco, CA, US
Selected to join Genentech’s highly competitive Translational Science Rotational Program (TSRP) in Translational Medicine Oncology. Directed the mechanistic validation of a novel therapeutic dependency in HR+ prostate and breast cancers, establishing its role as a key pro-proliferative regulator.Hypothesized and identified a key downstream substrate by integrating external dependency trends with internal proteomic and RNA-seq datasets.Validated a novel pharmacodynamic biomarker by demonstrating that target-mediated post-transcriptional degradation of the substrate drives the disease phenotype.Utilized Dox-inducible lentiviral systems to model multi-protein complex disruption, proving that therapeutic efficacy is strictly dependent on specific protein-protein associations.Characterized therapeutic windows for lead-target inhibition in anti-androgen-resistant models to inform early-stage clinical trial design.
Education
University of Southern California
Bachelor of Science - BS
2021 — 2025
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