Brett Williams
Principal Scientist @Nuvalent, Inc.
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WORK HISTORY
Principal Scientist @Nuvalent, Inc.
Boston, MA, US
EDUCATION
University of Pennsylvania
Doctor of Philosophy (PhD), Chemistry (Amos Smith)
University of California, Berkeley
Post doc with Dean Toste, Chemistry
University of Pittsburgh
Bachelor of Science (BS), Chemistry
SKILLS
ABOUT BRETT WILLIAMS
Experienced medicinal chemistry leader with 9+ years working across all stages of drug discovery - from determining hit finding strategy through GMP synthesis for Phase 1 clinical trials. Led chemistry effort on multiple programs for 5+ years Blueprint - Coinventor of two development candidates: BLU-782 (fidrisertib) and BLU-945. Managed an external team of 12 chemistsGoldfinch - Co-lead CDK5 chemistry effort. Identified two in vivo tool compounds which invalidated biological hypothesis. Managed external team of 20 chemists and supervised three Northeastern co-ops in onsite labs. Identified in vivo tool for CB1 antagonism program, which also invalidated biological hypothesis.Tango - Lead chemistry effort on three undisclosed programs. Program 1 was successfully in-licensed by Gilead Sciences. Program 2 culminated in DC-declaration. Program 3 is ongoing. Experienced with multiple hit-finding techniques (several HTS\'s, DEL, covalent and reversible fragment screening, virtual screening and multiple cell-based screening) and different inhibition modalities (e.g. allosteric-covalent and orthosteric). Managed 30+ external chemists in Ukraine and across China.
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