Bharath Naidu Matcha

About Bharath Naidu Matcha

Scientific Associate at Eli Lilly with a strong track record in Biologics Development and Molecular Diagnostics. I specialize in the end-to-end management of cell culture parameters to ensure consistent quality for large-scale production.What I Bring to the Table:•Upstream Process Expertise: Proven experience in configuring and monitoring SUB bioreactors (CHO, AAV, SF9) from N-2 to N stages, consistently improving culture yield and reliability.•Inventory & Digital Monitoring: Engineered and manage custom Power BI inventory management dashboards to streamline lab workflows, eliminating equipment downtime for 12+ consecutive months.•Data Visualization Innovation: Built and deployed PI Vision dashboards for wave reactors and filtration systems, enhancing real-time monitoring and reducing data review time by 50%.•Quality & Compliance Leadership: Maintain 100% GMP/GLP compliance and ensure readiness for FDA inspections through rigorous lab audits and equipment troubleshooting.•Advanced Lab Techniques: Hands-on proficiency in HPLC (Master Specialist certified), DNA/RNA isolation, and PCR.Based in Indianapolis | Always open to connecting with fellow scientists and innovators to discuss Bioprocessing, AI-driven Lab Automation, or the next wave of Biotech Innovation. Feel free to reach out!

Experience

1. Biochemist - Upstream Process Development

   Eli Lilly and Company

   Jan 2025 — Present · Indianapolis, IN, US

   My client I currently support Upstream Process Development (UPD) for both traditional Biologics and Gene Therapy programs. My day-to-day involves navigating the complexities of multiple cell lines, mainly CHO, AAV, and Sf9.Key Responsibilities & Technical Impact:•I manage the upstream workflow for CHO, AAV, and Sf9 cell lines. This includes everything from seed train scale-up (N-2 to N) to configuring DeltaV parameters for SUB bioreactors ranging from 5L to I execute modality-specific harvest operations:• For CHO: I perform Depth Filtration to clarify high-density cell cultures, focusing on filter capacity and pressure differentials.• For AAV: I utilize Tangential Flow Filtration (TFF) for cell concentration and diafiltration, ensuring high recovery of viral vectors.•Making inventory more efficient and I am working with a Power BI application to automate tracking. This ensured 100% material availability for our runs.•I developed PI Vision dashboards to monitor our wave reactors and filtration units, which cut down our manual data review time by about 25%.•Responsible for keeping our analytical tools—like the NOVA FLEX,ABL and Vi-CELL—calibrated and ready for daily runs and audits.

Education

• University of Houston-Clear Lake

  Master’s, Biotechnology

• Andhra University

  Bachelor of Science - BS, Biology/Biological Sciences, General

• Andhra University

  Master's degree, Biotechnology