Balaji Banoth
Scientist Iii @Igm Biosciences, Inc
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WORK HISTORY
Scientist Iii @Igm Biosciences, Inc
San Francisco, CA, US
In vivo functional lead to develop 4-1BB T-cell agonist program Test proof of concept IgG and IgM antibodies using in vitro and in vivo efficacy tumor models- Designed the in vivo study plan to assess in vivo efficacy, PD biomarker, and PK assessment- Collaborated with in vivo pharmacology team to execute the in vivo studies- Established in vitro functional assays Binding, T-cell activation, TDCC, ADCP, testing proof of concept IgG and IgM and drug candidate antibodies using human PBMC and mouse ex vivo immune cells- Developed a phopsho-Flow assay as part of assay development for secondary screening assay
EDUCATION
Kakatiya University
Bachelor of Science (BSc), Biotechnology
National Institute of Immunology
Doctor of Philosophy (Ph.D.), Cell Signaling
Savitribai Phule Pune University
MSc Biotechnology, Biotechnology
SKILLS
ABOUT BALAJI BANOTH
An innovative and experienced Immunology Senior Scientist specialized in inflammation, infectious diseases, immuno-oncology, and vaccinology. With over 13 years of combined academia and industry experience, I have led discovery and research projects in mRNA vaccines, immuno-oncology, and infectious disease therapeutics.I am proficient in designing and implementing novel mRNA-based vaccines for Influenza-A virus, Antibody biologics targeting T-cells, and Auto-inflammatory disorders. My expertise extends to managing in-vitro, ex-vivo, and in-vivo preclinical studies using primary cells, mice, ferret, and non-human primate models.As a project lead for mRNA vaccines, I successfully managed and mentored a team to support IND-enabling studies. My leadership qualities include fostering a culture of teamwork and a CAN DO - WILL DO attitude, driving exceptional quality research.Key competencies include:Developing and mentoring scientists in cellular and mouse models for immunology studiesExpertise in immunogenicity and reactogenicity assessment of Therapeutic and vaccine candidates using in vitro and in vivo modelsStrong leadership in managing exploratory research projects, understanding mechanisms of action, and supporting IND filingsI have a proven track record of impactful research contributions, including identifying novel innate immune signaling pathways and playing a pivotal role in the development of universal influenza vaccine candidates.
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