Aroop Sircar
- Role
- Senior Scientist at EMD Serono, Inc.
- Location
- Boston, MA, US
- LinkedIn followers
- 500 followers
About Aroop Sircar
Passionately embarks on new projects by combining business acumen with human warmth…
Experience
Senior Scientist
Jun 2018 — Present
Manage external partners to support the in vitro and in vivo studies required to validate novel biotherapeutics designed by me. Select preferred CRO after comprehensive comparative analysis by bidding from multiple vendors in Scientist.com. Integrate experimental data to improve existing molecular design. Ensure business continuity while working from home during early phases of COVID-19. Communicate proactively and engage with team members virtually, and support research projects and operational excellence. Chemokine / anti-Tumor Associated Antigen (TAA) antibody fusion protein • Externalize gene synthesis and plasmid preparation after vector design (using Geneious) • Coordinate in-house protein expression using externally synthesized DNA • Source difficult to find antigens by connecting with new vendors identified by exhaustive online searches • Outsource in vivo PD study • Design multiple molecular formats: X-Fc-Fab, X-Fab-Fc • Use transmigration assay data and ligand binding data to guide molecular design • Design linkers to ensure simultaneous antibody and chemokine binding • Predict immunogenicity by in silico analysis of genetic fusion junctions • Compare human, mouse & cynomolgus monkey ortholog sequences to predict cross-reactivity • Draft slides for presentation to executive leadership Anti COVID-19 therapeutics • Design molecules to bind SARS-CoV-2 spike protein • Analyze crystal structures to identify minimal domains for molecular assembly
Skills
- Affinity Maturation
- Computational Protein Engineering
- Structural Bioinformatics
- Pymol
- Computational Protein Design
- Bioinformatics
- Camelid Vhh Modeling
- Loop Building
- Interface Design
- Induced Fit Docking
- Humanization
- Moe
- Enhance Binding Affinity
- Stabilization
- Macromolecular Simulation
- Protein Modeling
- Python
- Protein-Protein Docking
- Algorithms
- Computational Alanine Scanning
- Protein Homology Modeling
- Protein Design
- Bioinformatics Developer
- Rosettadock
- Rosettainterface
- Elisa
- Docking
- Bioinformatician
- Cdr
- Linux
- Monte Carlo
- Computational Structural Bioinformatics
- Ensemble Docking
- Computational Interface Design
- CRO
- Perl
- Antibody Design
- C++
- Mac Os
- Antibody-Antigen Docking
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