Arun Mohanty
Principal Research Scientist @Vertex Pharmaceuticals
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WORK HISTORY
Principal Research Scientist @Vertex Pharmaceuticals
Boston, MA, US
High throughput compound screening, assay development and automation using different liquid handlers • Ligand binding and target engagement study of small molecules using cellular thermal shift assay in cells• Protein stabilization and degradation with small molecules in erythroid cells • Development of high throughput compound screening with RNA
EDUCATION
University of Mumbai
Doctor of Philosophy - PhD
ABOUT ARUN MOHANTY
SENIOR PRINCIPAL SCIENTIST Accomplished scientist and strategic leader with experience in protein engineering, biochemical and biophysical characterization of proteins, antibodies and RNA, cell biology and high-throughput screening contributing to FDA-approved CFTR modulators and small molecule drug discovery. Proven track record in leading cross-functional teams, mentoring junior scientists, and driving innovation in assay development. Adept at prioritization and execution of results to support important project decision. Core Competencies: Biopharmaceutical Research & Development (R&D)| Protein Engineering, Biochemistry, Biophysics, and Formulation | Chemical Biology | Cell Biology and Assay Development | High Throughput Screening (HTS)|Target Engagement | Lead Optimization | Team Building & Leadership | Cross-Functional Collaboration CAREER HIGHLIGHTS • Chemical & Cellular Biology: Molecular biology techniques, protein engineering, expression, stable cell line generation, target engagement (by CETSA), RNA CETSA, protein degradation, stability, and cytotoxicity assays, protein-protein interaction (PPI), proximity labeling, Immunoprecipitation, off-target assessment, mass spec, and MoA studies. • Biophysics & Biochemistry: Protein purification, biochemical, biophysical characterization of proteins and antibodies (DLS, SPR, ITC, MST, DSF, CETSA, FSEC, CD), crystallization, structure studies, design of experiments (DOE), cell free protein synthesis (IVTT), reconstitution and LNP preparation, RNA isolation, screening and characterization. • HTS & Assay Development: Miniaturized/automated assays (fluorescence, luminescence, AlphaLISA, HTRF, CETSA), hit validation, protein & RNA-targeted screening, robotic platforms (BioMek, Echo 650). • Leadership & Collaboration: Mentored junior scientists in addition to strategic collaboration with CROs and multidisciplinary teams in making key strategic decisions to accelerate drug discovery. • Review Committee: Active member of the Vertex Document Review Committee, and IND submission.
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