Arpita Sen
Principal Scientist (PhD) | Induced Proximity & Protein Interaction Screening | Building discovery platforms
- Role
- Principal Scientist at A-Alpha Bio
- Location
- Seattle, WA, US
- LinkedIn followers
- 500 followers
Experience
Principal Scientist
Mar 2025 — Present · Seattle, WA, US
Principal Scientist in partner-facing Platform R&D on a high-throughput protein interaction screening platform. Former Molecular Glue Discovery Team Lead, delivering milestone go/no-go packages and quarterly steering updates for biopharma partners.Highlights:• Scoped external collaboration workplans, success criteria, and controls; delivered decision-ready data packages.• Built and ran screening-to-validation workflow for molecular glue discovery (interaction screen, triage, orthogonal biochemical and cellular validation).• Scaled effector screening to 390+ unique effectors and established prioritization criteria and validation strategy.• Led and developed a team of 3 during the molecular glue phase, including promotion of a direct report; drove OKRs and matrix execution across Biology, Chemistry, Data Science, and TechOps. Core focus areas: induced proximity, molecular glues, protein interaction screening, validation strategy, partner governance, and decision-making frameworks.
Education
University of Calcutta, India
Master of Science (MS), Biophysics and Molecular Biology
2005 — 2007
Purdue University
Doctor of Philosophy - PhD, Cell/Cellular and Molecular Biology
2008 — 2013
Presidency College, University of Calcutta, India
Bachelor of Science (BS), Plant Sciences
2002 — 2005
Skills
- Lifesciences
- Cell Biology
- Biochemistry
- Molecular Biology
- Yeast
- Fluorescence Microscopy
- Protein Expression
- Life Sciences
- Molecular Cloning
- Research
- Confocal Microscopy
- Microscopy
- Pcr
- Western Blotting
- Protein Purification
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