Antonio Feula

About Antonio Feula

Medicinal chemist with 10+ years of experience in organic multi-step synthesis, drug discovery, medicinal and supramolecular chemistry. Track record of leadership and co-leadership of medicinal chemistry projects, cross-functional collaborations and CROs management2016 - Present• Designed lead compounds, optimizing for biochemical potency, in vitro and in vivo PK and PD• Proposed new synthetic routes and analogues, regularly influenced compound selection through use of working knowledge of SAR• Managed external collaborations with CROs (teams up to 12 organic chemists), leading weekly meetings,problem-solving synthesis of challenging targets to ensure timely advancement of the drug discovery project• Regularly presented project progress at team meetings, departmental meetings and company meetings• Collaborated with the DMPK on elucidation and characterization of clinical compounds’ metabolites• Published a scientific review in Journal of Medicinal Chemistry in collaboration with the DMPK department• Actively contributing to patent preparation20••••16• Synthesis of Small Organic Molecules as Detectors for Chemical Warfare Agents• Lecturer in Supramolecular Polymers• Synthesis of Supramolecular Polyurethanes and their Composites• Supervision of 6 PhD students• Laboratory management• Problem sessions for PhD and MSc students20••••12• New methodologies for the Asymmetric Synthesis of Azetidines and Pyrrolidines• Azetidines Palladium and Platinum Complexes to use as Organometallic Catalysts• Postgraduate Demonstrator to groups of 20 students on a weekly basis• Supervision of 5 junior scientists with their projects• Supervision of master and undergraduate students with their dissertations• Tutorial for A-level and undergraduate studentsSummer 2011• 3 months placement at East China University of Science and Technology, Shanghai, China with Prof. Wei-Ping Deng

Experience

1. Medicinal Chemistry Consultant

   Z Prime Therapeutics

   Nov 2025 — Present · San Francisco, CA, US

   Medicinal Chemistry Strategy - Lead one of the oncology programs - Advise on structure–activity relationship (SAR) strategies and lead candidate selection. Identify opportunities to improve potency, selectivity, ADME, and safety profiles- Synthetic Chemistry Support - Review synthetic routes and propose improvements to enhance efficiency, scalability, or yield. Advise on challenging synthetic transformations and troubleshooting. Evaluate CRO synthetic plans and provide technical feedback as needed- Program Guidance - Participate in weekly or bi-weekly project meetings to review data and guide next steps. Interpret biological data in a chemical context to help guide decision-making. Suggest follow-up compound designs based on SAR and PK/PD trends- Collaboration & Communication - Serve as a liaison between internal teams and external chemistry CROs or collaborators. Prepare clear reports and presentations summarizing findings and recommendations- IP & Documentation - Review and contribute to invention disclosures and patent strategy. Review and edit experimental documentation meets IP and regulatory standards.

Education

• Sapienza Università di Roma

  Bachelor's, Organic and Biomolecular Chemistry

  2002 — 2006

• University of Birmingham

  Doctor of Philosophy (PhD), Organic and Medicinal Chemistry

  2009 — 2012

• Sapienza Università di Roma

  Master's, Organic and Biomolecular Chemistry

  2006 — 2009

Skills

• Organic Chemistry
• Catalysis
• Chemistry
• Science
• Medicinal Chemistry
• Nmr Spectroscopy
• Rheology
• Nmr
• Spectroscopy
• Supramolecular Chemistry
• Polymers
• Polymer Chemistry
• Hplc
• Nanotechnology
• Organic Synthesis
• Laboratory
• Research
• Characterization
• Nuclear Magnetic Resonance (Nmr)
• Asymmetric Synthesis
• Organocatalysis
• Molecular Modeling
• Music
• Drug Discovery
• Ir Spectroscopy
• Organometallic Chemistry
• Music Production
• Mass Spectrometry
• Uv/Vis
• Biochemistry
• Materials Science
• Analytical Chemistry
• Laboratory Skills
• Assay Development
• Chemical Process Engineering
• Scanning Electron Microscopy
• Atomic Spectroscopy
• Mechanical Testing
• Protein Chemistry
• Protein Conjugation