Anjali Kumari

About Anjali Kumari

Bioinformatician with 9+ years of experience in NGS data analysis, workflow automation…

Experience

1. Scientific Manager i

   Excelra

   Nov 2022 — Present · Bengaluru, IN

   Omics Data Acquisition, Analysis, and Asset Creation for Specific Disease• Processed and harmonized multi-omics datasets using controlled vocabularies and co-normalization, performing DEG analysis, GSVA, cell type deconvolution, and pathway enrichment to interpret biological significance, providing key insights to support disease understanding and drug discovery initiatives.Compiling Missense/Nonsense Mutation Information for Gene-Indication Pairs from Public Resources• Built Python/R pipelines to curate and standardize missense/nonsense mutations from public databases (ClinVar, Orphanet, OMIM, GnomAD etc), generating mutation statistics for downstream genomic analyses.WES and RNA-seq Analysis of Patient-Derived Xenografts (PDX)• Processed and analysed WES and RNA-seq data from PDX models using nf-core/Nextflow pipelines. Performed variant calling (GATK), CNV detection (CNVkit), and differential expression analysis (DESeq2) to integrate genomic and transcriptomic profiles, identify pathway-level changes, and discover biomarkers linked to treatment response.Workshop Facilitation• Conducted workshops to train researchers on an in-house bioinformatics platform, driving adoption and effective utilization.Tool Enhancement & Deployment• Improved bioinformatics tools by adding features, Docker packaging, and RMarkdown documentation for scalable and reproducible use.Cloud-Based Data Processing• Processed RNA-seq data using LatchBio with nf-core/Nextflow pipelines for QC, alignment, and analysis, while leveraging TileDB for scalable storage and querying of raw and aligned data to enable efficient downstream analyses.Team Leadership & Project Management• Manage team, overseeing task delegation, progress tracking, and deliverables.• Acted as SME and Project Manager, handling client communications, requirement gathering, and bridging gaps between client and development teams.

Education

• Kendriya Vidyalaya

  Secondary High school and High school

• Jaypee Institute of Information Technology

  B.Tech, Biotechnology

  2010 — 2014

• IIIT Hyderabad

  Master of Technology - MTech, Bioinformatics

  2014 — 2016

Skills

• Sequence Alignment
• Python
• Namd
• Molecular Biology
• Sql
• Ngs Data Analysis
• Genetic Engineering
• Gene Expression Profiling
• Biotechnology
• Css
• Biochemistry
• Html Scripting
• C Language
• Genetic Enginee
• Pcr Primer Design
• Vmd
• Research
• Sds-Page
• C
• Qc for Ngs Samples
• Cell Culture
• Bioinformatics
• Competent Cell Preparation