Alyssa Watson

About Alyssa Watson

Senior Clinical Research Associate specializing in Phase 1–3 hematologic oncology clinical trials, with a focus on complex, multi-center Investigator-Sponsored and sponsor-supported studies across the Dana-Farber/Harvard Cancer Center network.At Massachusetts General Hospital Harvard Medical School, I lead site-level clinical operations for multiple leukemia trials, including PARADIGM, an AbbVie-supported AML study selected for the 2025 ASH Plenary Session. My work spans site initiation and monitoring, eligibility review, protocol compliance, data quality oversight, safety reporting, and cross-functional coordination.I’m particularly experienced in improving operational performance and data integrity through supporting enrollment strategy, resolving complex data and workflow issues, and preparing sites for safety reviews, data cuts, audits and inspections. I enjoy working at the intersection of clinical execution, collaboration, and problem-solving to support high-quality, patient-centered research.

Experience

1. Senior Clinical Research Associate

   Massachusetts General Hospital

   Jul 2025 — Present · Boston, MA, US

   Senior CRA supporting Phase 1–3 hematologic oncology clinical trials across the Dana-Farber/Harvard Cancer Center network. Lead site-level operations for both Investigator-Sponsored Trials (ISTs) and industry-supported studies, with a focus on complex leukemia protocols- Lead site-level clinical operations for DF/HCC leukemia trials, including PARADIGM, an AbbVie-supported AML study selected for the 2025 ASH Plenary Session- Perform eligibility review, informed consent oversight, SDR/SDV, AE/SAE documentation review, and protocol deviation management- Coordinate closely with investigators, coordinators, pharmacists, multi-center offices, and sponsor/CRO partners to support trial execution- Support enrollment strategy and site performance optimization, troubleshooting operational and logistical barriers to accrual- Maintain and review ISF/TMF documentation and support audit and inspection readiness- Prepare and submit IRB amendments, safety reports, and continuing reviews in accordance with institutional and regulatory requirements- Contribute to data quality improvements, issue resolution, and cross-functional communication across multi-site studies- Support several DF/HCC sites with IST clinical operations, ensuring protocol compliance, GCP/ICH adherence, and high-quality data

Education

• University of Massachusetts Lowell

  Bachelor of Arts - BA, Salutatorian of Economics, Concentration in Quantitative Reasoning, Magna cum Laude

• Worcester Polytechnic Institute

  Biotechnology