Alok Nerurkar

About Alok Nerurkar

Medicinal chemist with industry experience in small molecule drug discovery. I design, synthesize, and optimize lead compounds for potency, selectivity, physiochemical properties, in-vitro ADME, and PK by coupling multivariant SAR analysis with hypothesis driven medicinal chemistry design principles. As a member of a dynamic multidisciplinary team, I work closely with scientists internally as well as external collaborators including CROs, to resolve medicinal chemistry issues and successfully advance our drug discovery programs to deliver high-quality drug Key accomplishments*• Collaboratively advanced a CNS drug discovery program to deliver 2 small molecule lead candidates for the treatment of neurological disorders resulting in 1 granted patent.• Spearheaded a cross-functional collaboration focused on SAR exploration and hit-to-lead development efforts to discover 2 novel series of small molecule compounds leading to 2 patents.• A track record of productivity and problem solving in synthetic organic chemistry and medicinal chemistry, as demonstrated by 7+ publications, 20+ presentations, and 4 patent Medicinal chemistry and synthetic organic chemistry skills*• Design and synthesize hypothesis driven small molecule targets based on analysis of SAR and use of medicinal chemistry knowledge and principles.• Independently plan and execute multistep synthesis, purification, and characterization (NMR, LC-MS, HPLC) of complex small molecules as potential drug candidates.• Optimize in-vitro and in-vivo potency and selectivity of lead compounds as well as integration of ADME and DMPK data in the design of new drug candidates.*Areas of Expertise* • Multistep Organic Synthesis • Drug Design • Methodology Development • Library Synthesis• Total Synthesis • Process Optimization • Multiparameter Optimization • Project Management•SAR, ADME & DMPK Data Analysis • Project Management • CRO Management • NMR Spectroscopy • HPLC • LCMS • Chromatographic Purifications-> Let\'s Connect! Please send me a message on LinkedIn or reach out at a••••••@gmail.com to find out how I can add value to you.

Experience

1. Medicinal Chemist

   Crinetics Pharmaceuticals

   Dec 2023 — Present

Education

• University of Mumbai

  Master of Science - MS, Organic Chemistry

  2007 — 2009