Alessandro Bertero
Associate Professor @Università degli Studi di Torino
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WORK HISTORY
Associate Professor @Università degli Studi di Torino
Turin, IT
Principal Investigator of the ERC Starting Grant TRANS-3, directing the Armenise-Harvard Laboratory of Genome Architecting at the Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences.My group pursues a long-term vision of improving human sustainable wellbeing through molecular biology. For this, we combine fundamental discoveries and tool-building with translational goals. We have established a scalable iPSC culture platform, developed functional genomics technologies such as iPS2-seq and trans-C to decode differentiation and 3D genome organization, and engineered programmable gene circuits such as CIRI and GERALT to deterministically control cell fate. These innovations converge on two major applications: advancing regenerative medicine therapies for congenital heart disease, and enabling cellular agriculture as a sustainable alternative to factory farming.
EDUCATION
University of Cambridge
Doctor of Philosophy (Ph.D.)
Università degli Studi di Torino
Bachelor of Science (B.Sc.)
Università degli Studi di Torino
Master of Science (M.Sc.)
University of Cambridge
Master of Research (M.Res.)
SKILLS
ABOUT ALESSANDRO BERTERO
Group leader of the Armenise-Harvard Laboratory of Genome Architecting at the Molecular Biotechnology Center “Guido Tarone” of the University of Turin, and Associate Professor in the Department of Molecular Biotechnology and Health Sciences. Our long term vision is improving human sustainable wellbeing. We work to achieve this goal through the integrative application of stem cell biology, gene editing, genomics, and bioengineering to:(1) elucidate the genetic underpinnings of cardiac disease, the #1 killer worldwide;(2) develop regenerative medicine therapy for congenital heart disease, the most common life-threatening malformation in newborns; and, last but not least,(3) provide a cell-based alternative to factory farming, the main cause of biodiversity loss and a central contributor to climate change. These seemingly distinct aspects are actually deeply interconnected: elucidating the gene regulatory mechanisms behind cardiac development and disease provides the knowledge needed to develop cells and tissues for heart remuscularization, which in turn can be produced in even larger scale from animal cells for human consumption. Overall, our work has the potential to improve human life on earth from a holistic perspective: cradle to table and all the way to rocking chair.
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