Alan Rosales
Scientist i, Gene Therapy R & d @Sarepta Therapeutics
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WORK HISTORY
Scientist i, Gene Therapy R & d @Sarepta Therapeutics
Columbus, OH, US
Gene Therapy R&D Group:I focus on target discovery, characterization of preclinical animal models of neuromuscular and cardiac diseases, and demonstration of the mechanism of action of gene therapies through in vitro and in vivo preclinical studies. I also assist in designing and executing critical preclinical studies that evaluate efficacy and safety, helping to bridge the gap between early research and clinical application.
EDUCATION
Duke University
Doctor of Philosophy, Biomedical Engineering
Medgar Evers College Preparatory School
High School Diploma
University of Rochester
Bachelor of Science, Biomedical Engineering
The City College of New York
Master of Science, Biomedical Engineering
SKILLS
ABOUT ALAN ROSALES
I am currently a Scientist I in the Gene Therapy R&D group at Sarepta Therapeutics. I earned a PhD in Biomedical Engineering from Dr. Aravind Asokan’s Lab at Duke University, where my research was dedicated to pioneering advancements in gene therapy through the evolution of adeno-associated viruses (AAV). One focus of my work was engineering novel AAV variants capable of robust and effective gene transfer across multiple species, with a specific emphasis on kidney-targeted therapies. These efforts led to the discovery of new AAV variants with enhanced capabilities in diverse kidney models, ranging from murine to porcine, human kidney organoids, and nonhuman primate kidneys.My role extended beyond benchwork; I conceptualized, designed, and executed both in vivo and in vitro studies, contributing to a deeper understanding of AAV-mediated gene transfer. This research spanned multi-scale model systems, from organoids to large animal models, enabling translational insights that bridged the gap between laboratory findings and clinical application.
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