Abdul Hack Anas Abubakari
Research Assistant at Boston Children\'s Hospital - Orkin Lab
- Role
- Research Assistant at Boston Children's Hospital
- Location
- Middlebury, VT, US
- LinkedIn followers
- 500 followers
About Abdul Hack Anas Abubakari
My name is Abdul Abubakari, an international student from Ghana. I graduated from Middlebury College with a major in Molecular Biology and Biochemistry (MBBC) and a minor in Global Health due to my passion and desire to have a positive effect on the future of medicine and health in general across the world. My goal is to become a physician providing free, quality and affordable healthcare opportunities to people from all walks of life. Furthermore, I have philanthropic aspirations for students from impoverished families in my home country and soon across Africa. Currently, I work as a research assistant at the Orkin Lab. At the same time, I serve as a mentor to students and help guide, assist, and teach students to apply for admissions at colleges across the world and in the United States
Experience
Research Assistant
Sep 2024 — Present · Boston, MA, US
The Orkin laboratory has focused on transcriptional control in the hematopoiesis for several decades, including studies of the role of specific transcription factors in lineage determination and stem cell functions. More recently, our work has revealed how the switch from fetal (HbF) to adult hemoglobin (HbA) is controlled by the repressor BCL11A, and demonstrated how to leverage CRISPR gene editing to cripple BCL11A expression and reactivate HbF. These discoveries have been translated by biotech/pharma in clinical trials to treat patients with sickle cell disease and beta-thalassemia. Because gene editing, as currently employed, will not reduce the burden of disease more widely, we now seek to use small molecules to reactivate HbF based on what has been learned regarding the mechanism of action of BCL11A and regulation of its expression in erythroid cells. Our research entails interdisciplinary studies incorporating molecular and cell biology, chemistry, and structural biology.
Education
Uluslararasi Mevlana Anadolu Imam Hatip
High School Diploma, Liberal Arts and Sciences/Liberal Studies
2015 — 2019
Middlebury College
Bachelor's degree, Molecular Biology and Biochemistry; Minor in Global Health
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