Joshua Abbott
Senior Scientist, Biophysics & Biochemistry
- Role
- Senior Scientist Ii at Rapafusyn Pharmaceuticals
- Location
- Washington, DC, US
- LinkedIn followers
- 500 followers
About Joshua Abbott
Innovative biochemist/chemical biologist experience leading discovery programs from target ID through hit expansion for oncology, immunology, and rare diseases. Deep expertise in induced proximity and molecular glue mechanisms, biophysics (SPR/GCI/MST), structural biology, and computational chemistry. Proven record of cross‑functional leadership, CRO management, and data-driven decision making.
Experience
Senior Scientist Ii
Apr 2023 — Present · Washington, DC, US
Led the characterization of macrocyclic peptide-based molecular glues using biochemical and biophysical techniques. • Developed a comprehensive data analysis pipeline for identifying molecular glue hits from DEL screening. • Established workflows for computational docking of binary and ternary complexes and computational modeling to support target selection.• Utilized SPR, GCI, and MST for biophysical characterization, supporting hit identification, MOA studies and hit-to-lead optimization.• Managed protein design and production for assay development and structural biology efforts at CROs.
Education
Orchard Lake St. Mary's Preparatory
High School Diploma
2005 — 2009
University of Colorado Anschutz
Doctor of Philosophy (PhD), Biochemistry and Structural Biology
2015 — 2020
Kalamazoo College
Bachelor of Arts (B.A.), Chemistry, Biological Physics, Biochemistry and Molecular Biology
2010 — 2013
Skills
- Nmr
- Nuclear Magnetic Resonance (Nmr)
- Research
- Event Planning
- Hplc-Ms
- Spanish
- Hplc
- Assay Development
- Laboratory
- Protein Chemistry
- Chemistry
- Data Analysis
- Qualitative Research
- Organic Chemistry
- Statistics
- Molecular Biology
- Nmr Spectroscopy
- Public Speaking
- Lifesciences
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